Senior Modelling scientist / Pharmacokinetics scientist
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Are you a scientist with flair for mathematical modelling and knowledge of pharmacology, biology or physiology? Then come and join the Discovery & Development PKPD department.
About the department
In Discovery & Development PKPD you will have 14 dedicated and highly motivated colleagues supporting projects from early discovery to submission. The department is organisationally a part of Global Drug Discovery.
In our daily work the department has close collaboration with all therapeutic areas and research project teams as well as external collaborators and CROs.
Discovery & Development PKPD supports projects with pharmacokinetic (PK) and pharmacodynamic (PD) evaluation using PK and PKPD modelling starting from early discovery, to first in human studies and throughout the non-clinical development. Our evaluation is essential to secure project progress. The focus is to support and integrate in vitro and in vivo pharmacology, biology and ADME understanding in animals to select the best drug candidates for development. In the non-clinical development, the department is responsible for predicting human PK and PKPD, setting dose for First in Human (FIH) and reporting toxicokinetics to GLP as well as to give input to regulatory documents (e.g. IND, IMPD, NDA).
During clinical development the department conducts the interim PK evaluation in early phase 1 trials (e.g. single and multiple ascending dose), collaborates with clinical pharmacologists to support later clinical pharmacology studies (e.g. Drug-Drug-Interaction, renal and hepatic impairment), and addresses PKPD related questions and issues as they may arise.
The position
As a scientist you will be involved in a great variety of tasks related to PK and PKPD assessment, modelling and translation. You will be working in different interdisciplinary projects teams dependent on the project phase.
Key to your work is your modelling competencies and understanding of PK/PD and pharmacometrics supplied with an eager to apply your diverse analytical skillset to secure efficient project progression. You are expected to support one or more projects as well as supporting colleagues in the department with your special competencies and more general PK skills in case of resource bottlenecks. Focus is on the innovation and development of project specific analyses and models in close collaboration with other project scientists.
Successful candidates are dedicated scientists with an openminded approach who enjoy working in a dynamic environment and value sharing with colleagues and in the project teams.
Qualifications
- Ph.D within Physics, Math, Engineering, Life, Health or Medical sciences or equivalent pharmaceutical industry experience
- Strong understanding of timeseries analysis such as ordinary differential equations (for analysis of PK and PD) and pharmacometric principles
- Proficiency and programming skills with additional modelling or analytical software (Python, NONMEM, Monolix, PK-Sim, R, Matlab or SAS) is preferred
- Solid experience with and understanding of pharmacokinetics and modelling software (i.e. Phoenix WinNonlin/NLME or equivalent) are preferred, and experience with Physiologically Based Pharmacokinetics (PBPK) and/or Quantitative Systems Pharmacology (QSP) is an advantage
- 1-3 years of relevant pharmaceutical industry experience within R&D is preferred
- Excellent oral and written language communication skills. Business is conducted using UK English
- Excellent interpersonal and teamwork skills
Contact
For further information please contact Flemming S. Nielsen (+45 3079 3064).
Deadline
February 23rd 2020
Millions rely on us
To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.
Information og data
Denne ledige stilling har jobtypen "Afdelingsleder", og befinder sig i kategorien "Ledelse og personale".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 22.1.2020, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
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