Scientist / Sr. Scientist – In Vivo Pharmacology
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Ballerup
Dragonfly Therapeutics is seeking a highly motivated and experienced scientist with a strong focus on in vivo models of autoimmune diseases and neuroinflammation to join Dragonfly's Inflammation team in Copenhagen, Denmark.
The successful candidate will be responsible for setting up and developing in vivo models of autoimmune and neuroinflammation disorders to advance our drug candidates. The work will primarily involve establishing disease models in our own animal facility, conduct of the studies together with our animal technician and subsequent data analysis, and reporting of results at relevant meetings and in written reports. In addition to hands-on experiments, some work will involve collaboration with CROs to perform some of the models and endpoints, such as histology. The work may also encompass ex vivo analyses, such as immunophenotyping or measuring cytokines or mRNA expression in blood and relevant tissues. The candidate will work within cross-functional program teams to progress our drug candidates and take specific responsibility for the design and conduct of relevant in vivo models to support the projects. The successful candidate will refer to Kresten Skak - head of inflammation.
Responsibilities
Qualifications
About Dragonfly
Founded in 2015 by Dr. Tyler Jacks, head of the Koch Institute at MIT, Dr. David Raulet, one of the world's leading experts in Natural Killer (NK) cell biology, and Bill Haney, a longtime tech entrepreneur and investor, Dragonfly Therapeutics was launched to harness the power of the immune system to provide breakthrough treatments for patients – especially in areas where there are no effective treatments, today.
The company develops novel first-in-class therapeutics designed to harness Natural Killer cells and other cells of the innate immune system which can provide direct killing of disease promoting cell types, and provide a unique therapeutic window beyond current therapies for treatment of cancer and chronic inflammatory diseases.
We offer
Dragonfly TX is an exciting young company that offers great opportunities to develop your professional career and work with some of the brightest minds in breakthrough medicines for patients with urgent unmet medical needs.
Our employees are fundamental to our success, and we focus on attracting and retaining people with different experiences and backgrounds. We have a high-performing, collaborative culture characterized by respectful and diverse teams committed to our mission of patients first.
The Copenhagen site opened in October 2020, and we are currently 15 dedicated colleagues working out of the labs located in Ballerup.
Please visit our website for details.
Your application
Please apply by sending your CV and cover letter as soon as possible, no later than Sep 12th. Applythrough the button "Apply/Send ansøgning".
We are screening and interviewing for the position on an ongoing basis. For any further questions please email [email protected]
For more info, check out our career site https://dragonflytx.ofir.com
Denne jobannonce blev oprindeligt opslået på https://www.ofir.dk/
(Den originale annonce kan ses på: https://www.ofir.dk/showojob?ofirid=48dbd380)
Kilde: Jobnet.dk
The successful candidate will be responsible for setting up and developing in vivo models of autoimmune and neuroinflammation disorders to advance our drug candidates. The work will primarily involve establishing disease models in our own animal facility, conduct of the studies together with our animal technician and subsequent data analysis, and reporting of results at relevant meetings and in written reports. In addition to hands-on experiments, some work will involve collaboration with CROs to perform some of the models and endpoints, such as histology. The work may also encompass ex vivo analyses, such as immunophenotyping or measuring cytokines or mRNA expression in blood and relevant tissues. The candidate will work within cross-functional program teams to progress our drug candidates and take specific responsibility for the design and conduct of relevant in vivo models to support the projects. The successful candidate will refer to Kresten Skak - head of inflammation.
Responsibilities
- Design and perform studies, including PK/PD and efficacy, in mouse models including relevant ex vivo analysis to advance our growing pipeline
- Independently plan, perform, analyze, interpretate and report results from the studies in a timely manner
- Train animal technicians in new mouse models
- Interface with CROs for histological analysis and in vivo models and with vendors for acquisition of relevant materials and reagents
- Generate, manage, analyze, and maintain critical data with integrity and in a highly organized manner; Document data in electronic laboratory notebook and write technical reports
- Together with the animal technician ensure compliance with the animal experimentation legislation and keeping a high standard for animal ethics
- Work collaboratively within the Dragonfly Team.
Qualifications
- Ph.D. degree in In Vivo Pharmacology, Immunology, Cell Biology or similar relevant education with a strong background in autoimmune diseases and mouse models for these
- 3-6 years of relevant experience post-Ph.D., preferably with drug discovery and target validation experience from biotech/pharma (title commensurate with experience)
- A deep understanding of the immune system in human and mice is required, and a good understanding of the pathology of rheumatoid arthritis and multiple sclerosis is highly desirable.
- Understanding of the pathology of Alzheimer's disease is an advantage.
- Hands-on experience with animal models for autoimmune diseases is required, preferable CIA and EAE. Experience with Alzheimer’s Disease models is an advantage.
- Hands-on experience with ELISA, luminex, flow cytometry and histology is preferred
- Experience with testing of therapeutic and bispecific antibodies in animal models is an advantage
- Experience working with CROs and vendors is preferred
- Efficient time management and ability to work on several projects simultaneously
- Strong interpersonal skills and ability to effectively communicate with members of a multidisciplinary team
- Ability to work collaboratively, provide scientific insight, and communicate clearly in writing and orally
- Excellent record keeping abilities to document analytical data generated in support of regulatory requirements.
About Dragonfly
Founded in 2015 by Dr. Tyler Jacks, head of the Koch Institute at MIT, Dr. David Raulet, one of the world's leading experts in Natural Killer (NK) cell biology, and Bill Haney, a longtime tech entrepreneur and investor, Dragonfly Therapeutics was launched to harness the power of the immune system to provide breakthrough treatments for patients – especially in areas where there are no effective treatments, today.
The company develops novel first-in-class therapeutics designed to harness Natural Killer cells and other cells of the innate immune system which can provide direct killing of disease promoting cell types, and provide a unique therapeutic window beyond current therapies for treatment of cancer and chronic inflammatory diseases.
We offer
Dragonfly TX is an exciting young company that offers great opportunities to develop your professional career and work with some of the brightest minds in breakthrough medicines for patients with urgent unmet medical needs.
Our employees are fundamental to our success, and we focus on attracting and retaining people with different experiences and backgrounds. We have a high-performing, collaborative culture characterized by respectful and diverse teams committed to our mission of patients first.
The Copenhagen site opened in October 2020, and we are currently 15 dedicated colleagues working out of the labs located in Ballerup.
Please visit our website for details.
Your application
Please apply by sending your CV and cover letter as soon as possible, no later than Sep 12th. Applythrough the button "Apply/Send ansøgning".
We are screening and interviewing for the position on an ongoing basis. For any further questions please email [email protected]
For more info, check out our career site https://dragonflytx.ofir.com
Denne jobannonce blev oprindeligt opslået på https://www.ofir.dk/
(Den originale annonce kan ses på: https://www.ofir.dk/showojob?ofirid=48dbd380)
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Ballerup.
Jobbet er oprettet på vores service den 21.8.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Ballerup
- Mandag den 13. september 2021
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