Post doctoral position in Plant Biochemistry and Synthetic Biology: Functional characterization of
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Frederiksberg C
The Department of Plant and Environmental Science, Faculty of Science at the University of Copenhagen is offering a 2-year Post doctoral fellowships on “Functional characterization of sorghum CYP79 enzymes using knock-out mutants”. The Fellowship will commence on Wednesday November 1st, 2023 or as soon as possible thereafter.
The postdoc’s duties will include research within plant biochemistry and synthetic biology as well as teaching. The post may also include performance of other duties such as scientific mentoring.
Description of the scientific research environment
The Department of Plant and Environmental Sciences is a large department (400 employees) dedicated to plant, microbial, and environmental sciences (http://plen.ku.dk/english/ ). Further information on the Department is linked at http://www.science.ku.dk/english/about-the-faculty/organisation/.
The post doctoral position is financed by a five year Semper Ardens Grant from the Carlsberg Foundation “Crops for the future - Tackling the challenges of changing climates” and with the Plant Biochemistry Laboratory as the working place. The successful applicant will join the Synthetic Biology research group headed by Professor Birger Lindberg Møller. The project is carried out in collaboration with researchers at the Carlsberg Research Laboratory.
The Plant Biochemistry Laboratory is among the world leading laboratories within plant biochemistry and synthetic biology. Built on truly interdisciplinary research, a strong international network, a highly interactive international research environment and continuous strong support from external funds, the laboratory is making seminal contributions to science and has fostered a multitude of eminent researchers with influential positions in Denmark and abroad (http://plen.ku.dk/english/research/plant_biochemistry/ ).
Plants are Nature´s biochemists par excellence. As sessile organisms, their growth and development is totally dependent on highly specialized biosynthetic capacities, such as the ability to produce a plethora of structurally complex plant natural products (specialized metabolites). These natural products have highly diverse functional properties such as defense compounds towards herbivory and pests, attractants of pollinators, UV sunscreens and offer a way for the plant to communicate with other plants. Released volatiles may also act as signals in plant–plant communication or control tri-trophic interactions. Some natural products may be recycled, providing carbon, nitrogen, or sulfur to balance deficiencies in primary metabolism. This multiplicity of different physiological roles provides plants with metabolic plasticity to cope with environmental challenges. Basic understanding of these inter-acting processes is essential for targeted breeding of resilient crop plants for the future as part of the development of environmentally benign agricultural production systems.
Project description
Sorghum is a drought resistant crop grown in sub-tropical and tropical regions. Among the prominent natural products produced in sorghum is the cyanogenic glucoside dhurrin. The first step in dhurrin biosynthesis is catalyzed by a cytochrome P450 enzyme CYP79A1 converting tyrosine into the corresponding oxime. CYP71E1 and UGT85B1 enzymes convert the oxime to dhurrin. The three biosynthetic genes in the dhurrin pathway are localized in a gene cluster in the sorghum genome. The sorghum genome harbors eight additional CYP79 encoding genes separated in two phylogenetic groups. These CYP79 genes are scattered over the genome and with highly different and specific expression profiles. Sorghum knock-out mutants of each of the nine individual CYP79 genes have been prepared in collaboration with the Carlsberg Research Laboratory using FIND-IT technology. Based on the known expression patterns of the individual CYP79 genes and phenotypic changes observed in the knock-out mutants, cell and tissue specific metabolomic analyses, high resolution microscopy and mass-spectrometry imaging will be carried out to identify the in planta functionalities of the individual CYP79 enzymes. The study will be guided by results from functional expression of the individual CYP79 genes in yeast in a parallel post doctoral project. Discovered moon-lighting activities of the CYP79s would explain why the genomes of all higher plants harbor several genes encoding CYP79 enzymes.
Key scientific qualification areas
Plant biochemistry and molecular biology, metabolomics, enzyme biochemistry, bioimaging techniques, LC-MS technologies and spectral interpretations
Metabolic regulation as studied using transcriptomics, metabolomics and mass spectrometry imaging.
Knowledge of natural product metabolism
Publication record
The position is open from November 1st, 2023or as soon as possible thereafter.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
Negotiation for salary supplement is possible.
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Please include
The deadline for applications is Sunday 8 October 2023, 23:59 GMT+1.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.
You can read about the recruitment process athttp://employment.ku.dk/faculty/recruitment-process/.
Kilde: Jobnet.dk
The postdoc’s duties will include research within plant biochemistry and synthetic biology as well as teaching. The post may also include performance of other duties such as scientific mentoring.
Description of the scientific research environment
The Department of Plant and Environmental Sciences is a large department (400 employees) dedicated to plant, microbial, and environmental sciences (http://plen.ku.dk/english/ ). Further information on the Department is linked at http://www.science.ku.dk/english/about-the-faculty/organisation/.
The post doctoral position is financed by a five year Semper Ardens Grant from the Carlsberg Foundation “Crops for the future - Tackling the challenges of changing climates” and with the Plant Biochemistry Laboratory as the working place. The successful applicant will join the Synthetic Biology research group headed by Professor Birger Lindberg Møller. The project is carried out in collaboration with researchers at the Carlsberg Research Laboratory.
The Plant Biochemistry Laboratory is among the world leading laboratories within plant biochemistry and synthetic biology. Built on truly interdisciplinary research, a strong international network, a highly interactive international research environment and continuous strong support from external funds, the laboratory is making seminal contributions to science and has fostered a multitude of eminent researchers with influential positions in Denmark and abroad (http://plen.ku.dk/english/research/plant_biochemistry/ ).
Plants are Nature´s biochemists par excellence. As sessile organisms, their growth and development is totally dependent on highly specialized biosynthetic capacities, such as the ability to produce a plethora of structurally complex plant natural products (specialized metabolites). These natural products have highly diverse functional properties such as defense compounds towards herbivory and pests, attractants of pollinators, UV sunscreens and offer a way for the plant to communicate with other plants. Released volatiles may also act as signals in plant–plant communication or control tri-trophic interactions. Some natural products may be recycled, providing carbon, nitrogen, or sulfur to balance deficiencies in primary metabolism. This multiplicity of different physiological roles provides plants with metabolic plasticity to cope with environmental challenges. Basic understanding of these inter-acting processes is essential for targeted breeding of resilient crop plants for the future as part of the development of environmentally benign agricultural production systems.
Project description
Sorghum is a drought resistant crop grown in sub-tropical and tropical regions. Among the prominent natural products produced in sorghum is the cyanogenic glucoside dhurrin. The first step in dhurrin biosynthesis is catalyzed by a cytochrome P450 enzyme CYP79A1 converting tyrosine into the corresponding oxime. CYP71E1 and UGT85B1 enzymes convert the oxime to dhurrin. The three biosynthetic genes in the dhurrin pathway are localized in a gene cluster in the sorghum genome. The sorghum genome harbors eight additional CYP79 encoding genes separated in two phylogenetic groups. These CYP79 genes are scattered over the genome and with highly different and specific expression profiles. Sorghum knock-out mutants of each of the nine individual CYP79 genes have been prepared in collaboration with the Carlsberg Research Laboratory using FIND-IT technology. Based on the known expression patterns of the individual CYP79 genes and phenotypic changes observed in the knock-out mutants, cell and tissue specific metabolomic analyses, high resolution microscopy and mass-spectrometry imaging will be carried out to identify the in planta functionalities of the individual CYP79 enzymes. The study will be guided by results from functional expression of the individual CYP79 genes in yeast in a parallel post doctoral project. Discovered moon-lighting activities of the CYP79s would explain why the genomes of all higher plants harbor several genes encoding CYP79 enzymes.
Key scientific qualification areas
Plant biochemistry and molecular biology, metabolomics, enzyme biochemistry, bioimaging techniques, LC-MS technologies and spectral interpretations
Metabolic regulation as studied using transcriptomics, metabolomics and mass spectrometry imaging.
Knowledge of natural product metabolism
Publication record
The position is open from November 1st, 2023or as soon as possible thereafter.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
Negotiation for salary supplement is possible.
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Please include
- Curriculum vitae
- Diplomas (Master and PhD degree or equivalent)
- Research plan – description of current and future research plans
- Complete publication list
- Separate reprints of 3 particularly relevant papers
The deadline for applications is Sunday 8 October 2023, 23:59 GMT+1.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.
You can read about the recruitment process athttp://employment.ku.dk/faculty/recruitment-process/.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Frederiksberg C.
Jobbet er oprettet på vores service den 27.9.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Frederiksberg C
- Søndag den 08. oktober 2023
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