PhD Fellowship in 'Molecular mechanisms of eukaryotic chromosome replication' at the Center for Chromosome Stability ...
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A PhD position is available in the Center for Chromosome Stability (www.ccs.ku.dk) in a group headed by Assoc. Prof. Thomas Miller. The post is available from 1 October 2021 (or at a mutually agreed date). Highly motivated and committed candidates with an interest in eukaryotic DNA replication, DNA damage repair and cryo-electron microscopy (cryo-EM) are encouraged to apply.
The post is fully funded, although the post-holder will be encouraged to seek a personal fellowship to support their PhD stipend.
Our group and research
The CCS is a Center of Excellence funded by the Danish National Research Foundation, and has as its mission on understanding of how chromosomal instability causes human disease.
The CCS is embedded at the Department of Cellular and Molecular Medicine (www.icmm.ku.dk).
Project description
The objective of the project is to further our understanding the molecular mechanisms that eukaryotic cells use to overcome toxic DNA-protein crosslinks (DPCs) during chromosome replication. DPCs are a common form of DNA damage that arise frequently in human cells, and can induce genome instability by preventing the DNA replication machinery from accurately copying DNA. This project will involve in vitro reconstitution and biochemical characterisation of key steps in the eukaryotic DPC repair pathway, which will be imaged using time-resolved cryo-EM.
The research will benefit from access to cutting-edge electron microscopy facilities at the Core Facility for Integrated Microscopy (CFIM; https://www.cfim.ku.dk/), which houses Copenhagen’s node of the Danish Cryo-EM Facility.
The project will be overseen by Assoc. Prof. Thomas Miller ([email protected]), building on the experimental strategies developed in his recent study of replicative MCM helicase loading (Miller et al, Nature, 2019).
Start: 1 October 2021
Duration: 3 years as a PhD student
Weekly working hours: 37
Job description
Your key tasks as a PhD student at SUND are:
Profile
We are looking for a highly motivated and enthusiastic person with the following competences and experience:
Key criteria for the assessment of candidates
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. biochemistry, molecular biology, biophysics, structural biology, biology, cell biology.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
Other important criteria are:
Place of employment
The place of employment is at Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories.
Terms of employment and employment
The employment as a PhD fellow is full time (37 working hours per week in average) and for 3 years. Starting date is 1 October 2021, or by agreement.
The post is conditional upon the candidate’s successful enrolment in the Graduate School of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the candidate in consultation with the supervisors.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree.
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 27,788 /approx. EUR 3,729 EUR (April 2021-level) plus pension.
Questions
For specific information about the PhD scholarship, please contact the principal supervisor.
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’.
The application must include the following documents in PDF format:
Application deadline: 15 August 2021, 23.59 p.m. CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.
Kilde: Jobnet.dk
The post is fully funded, although the post-holder will be encouraged to seek a personal fellowship to support their PhD stipend.
Our group and research
The CCS is a Center of Excellence funded by the Danish National Research Foundation, and has as its mission on understanding of how chromosomal instability causes human disease.
The CCS is embedded at the Department of Cellular and Molecular Medicine (www.icmm.ku.dk).
Project description
The objective of the project is to further our understanding the molecular mechanisms that eukaryotic cells use to overcome toxic DNA-protein crosslinks (DPCs) during chromosome replication. DPCs are a common form of DNA damage that arise frequently in human cells, and can induce genome instability by preventing the DNA replication machinery from accurately copying DNA. This project will involve in vitro reconstitution and biochemical characterisation of key steps in the eukaryotic DPC repair pathway, which will be imaged using time-resolved cryo-EM.
The research will benefit from access to cutting-edge electron microscopy facilities at the Core Facility for Integrated Microscopy (CFIM; https://www.cfim.ku.dk/), which houses Copenhagen’s node of the Danish Cryo-EM Facility.
The project will be overseen by Assoc. Prof. Thomas Miller ([email protected]), building on the experimental strategies developed in his recent study of replicative MCM helicase loading (Miller et al, Nature, 2019).
Start: 1 October 2021
Duration: 3 years as a PhD student
Weekly working hours: 37
Job description
Your key tasks as a PhD student at SUND are:
- Carry through an independent research project under supervision.
- Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
- Participate in active research environments.
- Obtain experience with teaching or other types of dissemination related to your PhD project
- Write a PhD thesis on the grounds of your project.
- There will also be a research-based teaching in the ICMM curriculum, including at undergraduate level.
Profile
We are looking for a highly motivated and enthusiastic person with the following competences and experience:
- Must hold a Master’s degree in a related area of biochemistry, molecular biology, structural biology or biophysics.
- Must show evidence of publication-standard research, preferable within the areas of protein biochemistry or structural biology.
- Strong communication and collaboration skills, including the ability to work well in an international academic setting.
- Ability to work in a team of multidisciplinary scientists, and the potential to work independently with limited direction.
- Excellent written and oral communication skills in English.
Key criteria for the assessment of candidates
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. biochemistry, molecular biology, biophysics, structural biology, biology, cell biology.
As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
Other important criteria are:
- Grade point average achieved.
- Professional qualifications relevant to the PhD programme.
- Previous publications.
- Relevant work experience in DNA replication or repair, structural biology or biochemistry.
- Other professional activities.
- Curious mind-set with a strong interest in chromosome biology and cryo-electron microscopy.
- Personal drive and commitment to science.
Place of employment
The place of employment is at Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories.
Terms of employment and employment
The employment as a PhD fellow is full time (37 working hours per week in average) and for 3 years. Starting date is 1 October 2021, or by agreement.
The post is conditional upon the candidate’s successful enrolment in the Graduate School of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the candidate in consultation with the supervisors.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree.
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 27,788 /approx. EUR 3,729 EUR (April 2021-level) plus pension.
Questions
For specific information about the PhD scholarship, please contact the principal supervisor.
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’.
The application must include the following documents in PDF format:
- Motivated letter of application (max. one page)
- CV incl. education, experience, language skills and other skills relevant for the position
- Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
- Publication list (if possible).
Application deadline: 15 August 2021, 23.59 p.m. CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København N.
Jobbet er oprettet på vores service den 28.6.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København N
- Søndag den 15. august 2021
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