PhD in Metabolic Epigenetics
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Novo Nordisk Foundation Center for Basic Metabolic Research
University of Copenhagen
We are seeking a skilled PhD fellow to commence November 1, 2021, or after agreement.
Background
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.
The Center has around 260 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.
Our group and research
The successful applicant will work in the of Group Prof. Romain Barrès, which investigates how environmental and lifestyle factors influence long-term metabolic health in the present and future generations through epigenetic signals. We are an international lab group with a focus on hypothesis-driven research and a particular drive to make discoveries of high societal implication. You can read more about the work of the Barrès group here .
Project description
Enhancers are DNA regions that regulate the transcription of genes. Preliminary data indicate that certain enhancers are epigenetically remodeled in skeletal muscle tissue after long -term endurance training in men. These enhancer regions overlap with disease-associated genetic variants identified by Genome Wide Association Studies (GWAS). To further understand how physical exercise can regulate human health, we wish to perform functional testing and validation of genes targeted by these exercise-altered enhancers both in vitro in cultured metabolic cells and in vivo in rodent animal models. This project involves close collaboration with staff at CBMR and international collaboration with Prof. Stephen Simpson at the University of Sydney, and Prof. Marcelo Nobrega at the University of Chicago.
Principal supervisor
The principal supervisor is Prof. Romain Barrès, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen. [email protected].
Start: November 1, 2021
Duration: 3 years as a PhD fellow
Job Description
Your key tasks as a PhD student at SUND are:
Key criteria for the assessment of applicants
Essential criteria
Desirable
Place of employment
The place of employment is at the Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
Terms of employment
The employment as PhD fellow is full time and for 3 years starting November 1, 2021.
It is conditioned upon the applicant’s success¬ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree¬ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
Questions
For specific information about the PhD fellowship, please contact the principal supervisor.
General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:
Application deadline: July 12, 2021, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
Kilde: Jobnet.dk
University of Copenhagen
We are seeking a skilled PhD fellow to commence November 1, 2021, or after agreement.
Background
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.
The Center has around 260 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www.cbmr.ku.dk.
Our group and research
The successful applicant will work in the of Group Prof. Romain Barrès, which investigates how environmental and lifestyle factors influence long-term metabolic health in the present and future generations through epigenetic signals. We are an international lab group with a focus on hypothesis-driven research and a particular drive to make discoveries of high societal implication. You can read more about the work of the Barrès group here .
Project description
Enhancers are DNA regions that regulate the transcription of genes. Preliminary data indicate that certain enhancers are epigenetically remodeled in skeletal muscle tissue after long -term endurance training in men. These enhancer regions overlap with disease-associated genetic variants identified by Genome Wide Association Studies (GWAS). To further understand how physical exercise can regulate human health, we wish to perform functional testing and validation of genes targeted by these exercise-altered enhancers both in vitro in cultured metabolic cells and in vivo in rodent animal models. This project involves close collaboration with staff at CBMR and international collaboration with Prof. Stephen Simpson at the University of Sydney, and Prof. Marcelo Nobrega at the University of Chicago.
Principal supervisor
The principal supervisor is Prof. Romain Barrès, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen. [email protected].
Start: November 1, 2021
Duration: 3 years as a PhD fellow
Job Description
Your key tasks as a PhD student at SUND are:
- Carry through an independent research project under supervision
- Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
- Participate in active research environments including a stay at another research team
- Obtain experience with teaching or other types of dissemination related to your PhD project
- Teach and disseminate your knowledge
- Write a PhD thesis on the grounds of your project
Key criteria for the assessment of applicants
Essential criteria
- A Master’s degree within human biology or related discipline;
- Extensive knowledge in metabolism and prior experience in a research environment conducting research in metabolism and/or epigenetics;
- Hands-on experience with CRISPR technology, generation and cloning of expression vectors, PCR and RT-qPCR, gel-electrophoresis for DNA and protein (Western blot), ELISA, FACS, RNA interference, RNA- and ChIP-sequencing including library preparation, cell culture techniques and cellular respiration assays;
- A certificate in Laboratory Animal Science covering EU function ABD level, preferable from a FELASA-accredited course;
- Experience with animal work;
- Strong interpersonal and self-management skills;
- Excellent English language skills, both written and oral.
Desirable
- International lab experience;
- Previous co-authorship in peer-reviewed publications;
- Experience with teaching and supervising students.
Place of employment
The place of employment is at the Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
Terms of employment
The employment as PhD fellow is full time and for 3 years starting November 1, 2021.
It is conditioned upon the applicant’s success¬ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree¬ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
Questions
For specific information about the PhD fellowship, please contact the principal supervisor.
General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:
- Motivated letter of application (max. two pages) addressing each of the criteria point-by-point;
- CV incl. education, experience, language skills and other skills relevant for the position;
- Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do;
- Publication list (if relevant).
Application deadline: July 12, 2021, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København Ø.
Jobbet er oprettet på vores service den 29.6.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København Ø
- Mandag den 12. juli 2021
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