Postdoc in membrane interactions of photocatalytic nanoparticles
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København Ø
Department of Pharmacy
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen
The Department of Pharmacy is offering a one-year postdoctoral fellowship to investigate the interaction of photocatalytic nanoparticles with lipid membranes and lipopolysaccharides. The project will be carried out within the LEO Foundation Center for Cutaneous Drug Delivery, which integrates several disciplines, including physical chemistry, pharmaceutics, and molecular biology, to perform state-of-the-art research and to create innovative solutions within cutaneous drug delivery of both small and large molecules. The successful applicant will have the opportunity for cross-disciplinary research in collaboration with other researchers in the Center, as well as with external collaborators. The fellowship is available from October 1, 2021 or as soon as possible thereafter.
Project description
With increasing bacterial resistance against conventional antibiotics, nanoparticles are attracting interest as antimicrobials, offering advantages related to presently undeveloped bacterial resistance, as well as possibilities for triggerable antimicrobial effects for combatting challenging infections. Several mechanisms have been proposed for the antimicrobial activity of nanomaterials, including direct membrane destabilization, generation of reactive oxygen species, and heating induced either by light or magnetic fields. Despite considerable work demonstrating potent antimicrobial effects against various pathogens of such nanoparticles, studies on the mechanisms underlying such effects remain scarce. In the present project, focus is placed on investigating interactions of photocatalytic nanoparticles with bacterial membrane lipids and lipopolysaccharides, employing surface chemical methodologies. Through this, the project aims to provide a mechanistic foundation for further development of potent and selective nanoparticle-based therapeutics.
The successful candidate will be a member of the LEO Foundation Center for Cutaneous Drug Delivery. This project, which is funded by the Independent Research Fund Denmark, is directed at: (i) studies of the interaction of photocatalytic TiO2 nanoparticles with bacterial lipopolysaccharides and bacteria-mimicking lipid membranes, as well as (ii) how potency of such nanoparticles can be boosted by loading with antimicrobial peptides (AMP).
Your job
Your key tasks as a postdoc at the Faculty are to:
Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
Preferred qualifications
The ideal candidate for this project has hands-on experience with research with biological surface chemistry, particularly in investigations of lipid membranes, employing state-of-the-art surface chemistry methodologies for such studies, such as QCM-d, ATR-IR, ellipsometry, and neutron reflectometry. Furthermore, experience with antimicrobial peptides is an advantage.
Place of employment
The place of employment is at the department of Pharmacy, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
Terms of employment
The employment as postdoc is a full time position for one year. Starting date is October 1, 2021, or as soon as possible thereafter
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,600 DKK/ approx. 4,650 Euro (April 2020-level). (Check) Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
Questions
For further information you may contact project leader Professor Martin Malmsten; [email protected]; www.sund.ku.dk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Application procedure
Your online application, in English, must be submitted electronically by clicking ‘Apply now’ below. Your application must include the following documents/attachments – all in PDF format:
Deadline for application
July 31, 2021, 23:59 CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Interviews are expected to be held during the first two weeks of August.
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
Kilde: Jobnet.dk
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen
The Department of Pharmacy is offering a one-year postdoctoral fellowship to investigate the interaction of photocatalytic nanoparticles with lipid membranes and lipopolysaccharides. The project will be carried out within the LEO Foundation Center for Cutaneous Drug Delivery, which integrates several disciplines, including physical chemistry, pharmaceutics, and molecular biology, to perform state-of-the-art research and to create innovative solutions within cutaneous drug delivery of both small and large molecules. The successful applicant will have the opportunity for cross-disciplinary research in collaboration with other researchers in the Center, as well as with external collaborators. The fellowship is available from October 1, 2021 or as soon as possible thereafter.
Project description
With increasing bacterial resistance against conventional antibiotics, nanoparticles are attracting interest as antimicrobials, offering advantages related to presently undeveloped bacterial resistance, as well as possibilities for triggerable antimicrobial effects for combatting challenging infections. Several mechanisms have been proposed for the antimicrobial activity of nanomaterials, including direct membrane destabilization, generation of reactive oxygen species, and heating induced either by light or magnetic fields. Despite considerable work demonstrating potent antimicrobial effects against various pathogens of such nanoparticles, studies on the mechanisms underlying such effects remain scarce. In the present project, focus is placed on investigating interactions of photocatalytic nanoparticles with bacterial membrane lipids and lipopolysaccharides, employing surface chemical methodologies. Through this, the project aims to provide a mechanistic foundation for further development of potent and selective nanoparticle-based therapeutics.
The successful candidate will be a member of the LEO Foundation Center for Cutaneous Drug Delivery. This project, which is funded by the Independent Research Fund Denmark, is directed at: (i) studies of the interaction of photocatalytic TiO2 nanoparticles with bacterial lipopolysaccharides and bacteria-mimicking lipid membranes, as well as (ii) how potency of such nanoparticles can be boosted by loading with antimicrobial peptides (AMP).
Your job
Your key tasks as a postdoc at the Faculty are to:
- Develop, optimise and evaluate surface chemistry methods (ATR-IR, QCM-d, neutron reflectometry) to study the interaction of TiO2 nanoparticles with bacterial lipopolysaccharides and lipid membranes.
- Write scientific manuscripts on the grounds of your research results
- Participate in Center activities
- Participate in national and international conferences and scientific meetings
- Participate in teaching activities at the department
- Co-supervise PhD and MSc students
Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have obtained a relevant PhD degree prior to the starting date
- You are experienced in surface chemistry methodologies
- You are experienced in surface chemistry studies of lipid membranes
- Proficient communication skills and ability to work in teams
- Excellent English skills, written and spoken
Preferred qualifications
The ideal candidate for this project has hands-on experience with research with biological surface chemistry, particularly in investigations of lipid membranes, employing state-of-the-art surface chemistry methodologies for such studies, such as QCM-d, ATR-IR, ellipsometry, and neutron reflectometry. Furthermore, experience with antimicrobial peptides is an advantage.
Place of employment
The place of employment is at the department of Pharmacy, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
Terms of employment
The employment as postdoc is a full time position for one year. Starting date is October 1, 2021, or as soon as possible thereafter
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,600 DKK/ approx. 4,650 Euro (April 2020-level). (Check) Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
Questions
For further information you may contact project leader Professor Martin Malmsten; [email protected]; www.sund.ku.dk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Application procedure
Your online application, in English, must be submitted electronically by clicking ‘Apply now’ below. Your application must include the following documents/attachments – all in PDF format:
- Cover letter (approx. one page) describing your background, qualifications, interest and motivation for applying for this position
- CV, incl. education, work/research experience, language skills and other skills relevant for the position
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement with defence date from the supervisor will do.
- Other information for consideration, e.g. list of publications and relevant certificates
- Names and contact details of references and/or recommendation letters
Deadline for application
July 31, 2021, 23:59 CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Interviews are expected to be held during the first two weeks of August.
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København Ø.
Jobbet er oprettet på vores service den 30.6.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København Ø
- Lørdag den 31. juli 2021
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