PhD fellow for The Department of Infectious Disease Immunology
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We are looking for a dedicated PhD student for our project “Targeting the respiratory and the gastrointestinal tract with new Nanoparticle-based vaccine technologies to generate protective memory immunity”
The Department and research group
We focus on research and development of next-generation vaccines and diagnostic tools, primarily within tuberculosis, chlamydia, Streptococcus, and vaccine adjuvants. We conduct both basic and translational research and we are highly rated internationally. As part of the Center for Vaccine Research at Statens Serum Institut, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the National Institutes of Health, the European Commission and the Danish Research Council.
About the project
The respiratory and the gastrointestinal tract are the targets for many pathogens, and the ability to protect these sites with a vaccine is a high priority. We have generated a panel of new advanced adjuvant systems with the ability to activate the innate and adaptive immune systems in different ways, and we wish to test these adjuvant systems for their ability to target and protect the respiratory tract against infection with Streptococcus Pyogenes. We moreover wish to identify the correlates of protection, and in particular focus on Th17 T cells, as we recently showed that these cells in the airway tissue correlated with protection. In order to study the in vivo function of the Th17 T cells, we recently generated an IL-17 fate-reporter (il17aCreR26ReYFP) mouse, where all cells with a history of IL-17 production (e.g. Th17 T cells) are permanently marked as eYFP+ cells, and therefore detectable by flow cytometry. We therefore have a unique possibility to study the development of Th17 T cells, and characterize all the Th17 T cell subsets in the different locations irrespective of their cytokine expression. Some of these analyses will be done at a single cell level where we intend to perform single cell sequencing on all local Th17 T cells. The hope is that this will identify new Th17 T cell subsets and identify their role against infection in the respiratory tract. Regarding the gastrointestinal tract, we will use other state-of-the-art Nano technologies to deliver the vaccines to the M-cells of the intestines, and subsequently to the Peyers patch. We will thereafter confirm this via advanced immunological methods, and as mentioned above study the induced local immunity in detail.
The PhD fellow will be part of a dynamic, international team of scientists, technicians and other students, who are all passionate about global health, infection immunity and vaccine research.
In summary, the PhD fellow will:
Your background, professional and personal qualifications
We are looking for a dedicated student with an interest in infectious disease immunology and vaccines. As a PhD fellow, you will investigate trafficking of T cells in the infected lung using flow cytometry and confocal microscopy of fixed tissue samples. The project comprises adoptive transfer experiments with transgenic T cells, development of new animal models and sequence analysis.
An integral part of the project is a research stay at one of our collaborating institutions.
We expect you to have a Master’s degree within Life Sciences and that you are critical and creative. A hard-working and self-motivated mentality is key to the applicant’s success. Furthermore we would like you to have the following qualifications:
Last but not the least you are independent and goal orientated with a good team spirit.
Terms of employment
You will be employed as a research assistant (videnskabelig assistent) until the date from where you are enrolled as a ph.d.-student at a Danish University. During this period, you will be employed in accordance with the current collective agreement between the Danish Ministry of Taxation and the Danish Confederation of Professional Associations as well as the circular on the job structure for academic staff with research tasks at government research institutions.
From the time of enrolment as a ph.d.-student (ph.d.-studerende), you will be transferred to employment as a Ph.D. fellow (ph.d.-stipendiat). The employment is three years and is covered by the collective agreement between the Danish Ministry of Taxation and the Danish Confederation of Professional Associations, including Appendix 5 concerning Ph.D. Fellows.
Information
For further details and informal enquiries please contact Senior Scientist Jes Dietrich +45 3268 3819 / [email protected].
Application
Click “apply for position” to send your application with CV and copies of relevant academic diplomas.
Kilde: Jobnet.dk
The Department and research group
We focus on research and development of next-generation vaccines and diagnostic tools, primarily within tuberculosis, chlamydia, Streptococcus, and vaccine adjuvants. We conduct both basic and translational research and we are highly rated internationally. As part of the Center for Vaccine Research at Statens Serum Institut, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the National Institutes of Health, the European Commission and the Danish Research Council.
About the project
The respiratory and the gastrointestinal tract are the targets for many pathogens, and the ability to protect these sites with a vaccine is a high priority. We have generated a panel of new advanced adjuvant systems with the ability to activate the innate and adaptive immune systems in different ways, and we wish to test these adjuvant systems for their ability to target and protect the respiratory tract against infection with Streptococcus Pyogenes. We moreover wish to identify the correlates of protection, and in particular focus on Th17 T cells, as we recently showed that these cells in the airway tissue correlated with protection. In order to study the in vivo function of the Th17 T cells, we recently generated an IL-17 fate-reporter (il17aCreR26ReYFP) mouse, where all cells with a history of IL-17 production (e.g. Th17 T cells) are permanently marked as eYFP+ cells, and therefore detectable by flow cytometry. We therefore have a unique possibility to study the development of Th17 T cells, and characterize all the Th17 T cell subsets in the different locations irrespective of their cytokine expression. Some of these analyses will be done at a single cell level where we intend to perform single cell sequencing on all local Th17 T cells. The hope is that this will identify new Th17 T cell subsets and identify their role against infection in the respiratory tract. Regarding the gastrointestinal tract, we will use other state-of-the-art Nano technologies to deliver the vaccines to the M-cells of the intestines, and subsequently to the Peyers patch. We will thereafter confirm this via advanced immunological methods, and as mentioned above study the induced local immunity in detail.
The PhD fellow will be part of a dynamic, international team of scientists, technicians and other students, who are all passionate about global health, infection immunity and vaccine research.
In summary, the PhD fellow will:
- develop vaccine strategies that target the mucosa in the respiratory or the gastrointestinal tract
- study basic cellular and humoral local and systemic immune responses after mucosal administration with experimental adjuvanted vaccines or vaccines generated via new Nano-based technologies
- establish in vitro and in vivo models for investigating immunity induced by vaccines in mucosal tissue
- study vaccine-host interactions with special emphasis on role of both APC subsets and T cell subsets
- study the interplay between the pathogen and the vaccine induced immunity.
Your background, professional and personal qualifications
We are looking for a dedicated student with an interest in infectious disease immunology and vaccines. As a PhD fellow, you will investigate trafficking of T cells in the infected lung using flow cytometry and confocal microscopy of fixed tissue samples. The project comprises adoptive transfer experiments with transgenic T cells, development of new animal models and sequence analysis.
An integral part of the project is a research stay at one of our collaborating institutions.
We expect you to have a Master’s degree within Life Sciences and that you are critical and creative. A hard-working and self-motivated mentality is key to the applicant’s success. Furthermore we would like you to have the following qualifications:
- training in immunology and immune assays i.e. Flow Cytometry, microscopy, qPCR and ELISA
- experience with BSL-II lab work, image analysis and planning/execution of animal experiments is an advantage
Last but not the least you are independent and goal orientated with a good team spirit.
Terms of employment
You will be employed as a research assistant (videnskabelig assistent) until the date from where you are enrolled as a ph.d.-student at a Danish University. During this period, you will be employed in accordance with the current collective agreement between the Danish Ministry of Taxation and the Danish Confederation of Professional Associations as well as the circular on the job structure for academic staff with research tasks at government research institutions.
From the time of enrolment as a ph.d.-student (ph.d.-studerende), you will be transferred to employment as a Ph.D. fellow (ph.d.-stipendiat). The employment is three years and is covered by the collective agreement between the Danish Ministry of Taxation and the Danish Confederation of Professional Associations, including Appendix 5 concerning Ph.D. Fellows.
Information
For further details and informal enquiries please contact Senior Scientist Jes Dietrich +45 3268 3819 / [email protected].
Application
Click “apply for position” to send your application with CV and copies of relevant academic diplomas.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København S.
Jobbet er oprettet på vores service den 11.8.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København S
- Torsdag den 01. september 2022
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