Post Doc to the Department of Infectious Disease Immunology at Statens Serum Institut
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About the Department of Infectious Disease Immunology
The Department of Infectious Disease Immunology focuses on research and development of next-generation vaccines and diagnostic tools, primarily within tuberculosis, chlamydia, streptococcus, and vaccine adjuvants. The Department conducts both basic and translational research and is highly rated internationally. As part of the SSI Center for Vaccine Research, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the National Institutes of Health, European Commission and the Danish Research Council.
The present Post Doc project will focus on the genital tract and you will be part of a dynamic, international team encompassing scientists, technicians and other students, who are all passionate about global health, infection immunity and vaccine research.
The project
This project aims to deliver a new understanding of Th17 T cells and their role in combatting an infection with the bacterium Chlamydia trachomatis (C.t.). Globally, an estimated 131 million new cases of Chlamydia occur annually.There is a great need for a chlamydia vaccineand WHO recently initiated a global vaccine roadmap targeting sexually transmitted infections, among them C.t. The optimal immune response against this infection has yet to be fully identified. In particular, the role of Th17 T cells is not known, and conflicting results have been obtained on these cells.
We have recently obtained preliminary data that suggest Th17 T cells as key players in protecting the genital tract against a C.t. infection. To further study this, we generated an IL-17 fate-reporter mouse strain, and showed that Th17 T cells actually exist as many subsets in a C.t. infected genital tract. To investigate these subsets it is important that we examine expression of all genes in these cells, on a single cell level. As we are experts in chlamydia, Th1/Th17 T cell immunology, chlamydia animal models, have a strong collaboration with university of Copenhagen (KU), and have just developed an IL-17 fate-reporter mouse strain (in which we can track all Th17 T cells, even if they lose IL17 expression), we are in a unique position to initiate such a project, and characterize the protective role of Th17 T cell subsets against infection with C.t..
In summary, the Post doc will:
About the job
We are looking for a dedicated Post Doc with an interest in infectious disease immunology and vaccines. You will investigate trafficking of T cells in the infected genital tract using flow cytometry and other methods. The project comprises adoptive transfer experiments with transgenic T cells, development of new animal models and sequence analysis.
Your qualifications:
Terms of employment
The employment is of 3 years duration. The employment will be in accordance with the terms of the collective agreement between the Danish Ministry of Taxation and the Danish Federation of Professional Associations (AC-overenskomsten) and the Danish Ministry of Taxation’s circular concerning the job structure for scientific staff working with research at sector research institutions (Stillingsstruktur for videnskabeligt personale med forskningsopgaver ved sektorforskningsinstitutioner).
Your research qualifications will be assessed by a scientific assessment committee in accordance with the current Danish rules for employment of scientific staff working with research at sector research institutions in Denmark.
Further information
For further details and informal enquiries please contact Senior Scientist Jes Dietrich +45 32 68 3819 / [email protected].
Application
Your application must be submitted electronically by clicking “Apply now” below. Please include cover letter, CV and other relevant documents. Interviews are expected to take place in week 43-44.
Kilde: Jobnet.dk
The Department of Infectious Disease Immunology focuses on research and development of next-generation vaccines and diagnostic tools, primarily within tuberculosis, chlamydia, streptococcus, and vaccine adjuvants. The Department conducts both basic and translational research and is highly rated internationally. As part of the SSI Center for Vaccine Research, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the National Institutes of Health, European Commission and the Danish Research Council.
The present Post Doc project will focus on the genital tract and you will be part of a dynamic, international team encompassing scientists, technicians and other students, who are all passionate about global health, infection immunity and vaccine research.
The project
This project aims to deliver a new understanding of Th17 T cells and their role in combatting an infection with the bacterium Chlamydia trachomatis (C.t.). Globally, an estimated 131 million new cases of Chlamydia occur annually.There is a great need for a chlamydia vaccineand WHO recently initiated a global vaccine roadmap targeting sexually transmitted infections, among them C.t. The optimal immune response against this infection has yet to be fully identified. In particular, the role of Th17 T cells is not known, and conflicting results have been obtained on these cells.
We have recently obtained preliminary data that suggest Th17 T cells as key players in protecting the genital tract against a C.t. infection. To further study this, we generated an IL-17 fate-reporter mouse strain, and showed that Th17 T cells actually exist as many subsets in a C.t. infected genital tract. To investigate these subsets it is important that we examine expression of all genes in these cells, on a single cell level. As we are experts in chlamydia, Th1/Th17 T cell immunology, chlamydia animal models, have a strong collaboration with university of Copenhagen (KU), and have just developed an IL-17 fate-reporter mouse strain (in which we can track all Th17 T cells, even if they lose IL17 expression), we are in a unique position to initiate such a project, and characterize the protective role of Th17 T cell subsets against infection with C.t..
In summary, the Post doc will:
- Develop vaccine strategies that target the mucosa in the genital tract
- Study basic cellular and humoral local and systemic immune responses after mucosal administration with experimental adjuvanted vaccines
- Establish in vitro and in vivo models for investigating immunity induced by vaccines in mucosal tissue
- Study vaccine-host interactions with special emphasis on role of both APC subsets and T cell subsets
- Study in detail the interplay between the pathogen and the vaccine induced immunity.
- Work with single cell sequencing technology.
About the job
We are looking for a dedicated Post Doc with an interest in infectious disease immunology and vaccines. You will investigate trafficking of T cells in the infected genital tract using flow cytometry and other methods. The project comprises adoptive transfer experiments with transgenic T cells, development of new animal models and sequence analysis.
Your qualifications:
- Highly motivated student holding a PhD degree in Life Sciences
- Critical and creative thinking is expected
- Hard-working self-motivated mentality is key to the applicant’s success
- Training in immunology and immune assays i.e. Flow Cytometry, microscopy, qPCR and ELISA
- Experience with BSL-II lab work, image analysis and planning/execution of animal experiments is an advantage
- Experience with single cell sequencing
- Dynamic, independent and goal orientated with a good team spirit.
Terms of employment
The employment is of 3 years duration. The employment will be in accordance with the terms of the collective agreement between the Danish Ministry of Taxation and the Danish Federation of Professional Associations (AC-overenskomsten) and the Danish Ministry of Taxation’s circular concerning the job structure for scientific staff working with research at sector research institutions (Stillingsstruktur for videnskabeligt personale med forskningsopgaver ved sektorforskningsinstitutioner).
Your research qualifications will be assessed by a scientific assessment committee in accordance with the current Danish rules for employment of scientific staff working with research at sector research institutions in Denmark.
Further information
For further details and informal enquiries please contact Senior Scientist Jes Dietrich +45 32 68 3819 / [email protected].
Application
Your application must be submitted electronically by clicking “Apply now” below. Please include cover letter, CV and other relevant documents. Interviews are expected to take place in week 43-44.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København S.
Jobbet er oprettet på vores service den 7.10.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København S
- Lørdag den 19. november 2022
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