Scientist or Senior Scientist for Oligonucleotide Medicinal Chemistry

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Scientist or Senior Scientist for Oligonucleotide Medicinal Chemistry


Denmark, Capital, Copenhagen

  • Job facts


We are looking for a highly skilled medicinal chemist to join our team at the Roche Innovation Center Copenhagen (RICC) in a 3-year temporary position starting in February/March 2021. This is an exciting opportunity to join the Synthesis and Optimisation Department position as a Scientist or Senior scientist within Oligonucleotide Medicinal Chemistry.

Background

At RICC, we are focused on the early Research and Development of new drug molecules based on chemically synthesized oligonucleotides. As part of Roche pharma Research and Early Development (pRED), at RICC we cover the design, discovery, optimization, and synthesis of nucleic acid-based medicines. The site is located in Hørsholm, 20 km north of Copenhagen.

You will have colleagues with diverse backgrounds such as chemistry, molecular biology and bioinformatics. We work in a highly collaborative, open and engaging environment where we continuously strive to push the boundaries for innovation and development.

We offer an exciting and challenging job in an international environment where you will be given the opportunity to help realize the potential of nucleic acid-based medicines for patients. Because we know that our employees are critical to our success, we are dedicated to remaining a great place to work and to providing employees with development opportunities, services and benefits that allow them to bring the best to the business and to their personal lives.

The team

Synthesis and Optimization is in the RNA Molecule Research (RMR) chemistry department. We collaborate with the different departments in RMR, as well as across the global organization in Roche, in order to bring molecules from initial preclinical development to patients.

The department consists of Scientists and Associates collaborating to develop and optimize oligonucleotide-based chemistries. We have an explorative and open mindset to always optimize and push current chemistry technologies and processes as well as developing new innovative technologies to constantly be able to deliver the best oligonucleotide drug candidates possible.

We are the chemistry experts of RMR and, together with our partners, we generate scientific and technical knowledge to enable the discovery of novel molecules with diverse modes of action for unmet medical needs across a variety of disease therapeutic areas. As a core, we build our strength on a broad diversity of hardworking and highly skilled technical experts and chemists who are delivering and innovating in the space of RNA-based therapeutics.

The job

We seek an excellent chemist with a strong and broad scientific and technical profile to develop oligonucleotide based drug candidates.

You will find yourself in a dynamic matrix structure with changing tasks and will be working in close collaboration with project leaders, scientists and associates in an agile environment.

In this role, you will design, synthesize and purify modified oligonucleotides, optimize oligonucleotide chemistries and processes in the laboratory, as well as participate in project teams representing Synthesis and Optimization in order to enable the lead compound identification/optimization and shape the overall strategy of the drug discovery projects.

Your qualifications

The successful applicant is expected to have a PhD or equivalent relevant experience in synthetic organic chemistry, medicinal chemistry, chemical engineering, or a related discipline. It is very important that you thrive in the laboratory environment and that you are passionate about developing next generation drug molecules.

In addition, the ideal candidate has:

  • In-depth knowledge of synthetic organic chemistry and medicinal chemistry is a requirement

  • Ability to independently design new successful multi-step synthetic routes for new monomers and other small molecules

  • Experience and success with independently generating new ideas and maturing them together with colleagues

  • Experience with solid phase synthesis and/or nucleosides/nucleotides is an advantage

  • Experience with purification techniques such as HPLC - reverse phase, ion exchange and/or size exclusion is an advantage

  • Several years of experience from the pharmaceutical industry is an advantage

  • Proven track record from previous work (i.e. examples in the peer reviewed or patent literature) is an advantage

  • Excellent written and verbal communication skills are essential; fluency in English is required


Your application

Please submit your application via application link no later than January 10 2021. We will review the applications continuously and close the recruitment process once we have found the right candidate, so we encourage you to apply as soon as possible.

The application must include:

  • Application (motivated cover letter) addressing where you stand with respect to the qualifications mentioned

  • CV, including list of publications


If you have additional questions about the role, please contact Dennis Hansen ([email protected]) or Erik Funder ([email protected]), Team leaders in Synthesis and Optimisation.

If you are proud of contributing and feel you have the dedication to teamwork and innovation that we are seeking, then Roche is the organization for you. Every role at Roche plays a part in making a difference to patients’ lives. If you want to work in a passionate team, make your mark & improve lives, apply now.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Roche is an equal opportunity employer.

Research & Development, Research & Development Research

  • Who we are At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

    Roche is an equal opportunity employer.

  • Job facts
    • Location Denmark, Capital, Copenhagen
    • Function Research & Development
    • Subfunction Research
    • Schedule Full time
    • Job level Individual contributor
    • Job type Temporary (Fixed Term)
    • Division Roche Pharmaceuticals
    • Posted since 2020/12/17
    • Posted until 2021/01/10
    • Job-ID 202012-131084


  • Get in touch Jessica Lucas



Information og data

Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".

Arbejdsstedet er beliggende i København

Jobbet er oprettet på vores service den 17.12.2020, men kan have været deaktiveret og genaktiveret igen.

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