Postdoctoral Fellowship in Functional Genomics of Human Adipocytes in Collaboration with the Broad Institute, Boston
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Odense M
The Mandrup group at the Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding postdoctoral candidates who are interested in joining our group to investigate functional genomics of human adipocyte differentiation and to link genome variation to function. We are particularly interested in candidates with a mixed experimental and computational background. The fellowship is part of the Human Gene Regulation Map project within the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease and is available from 1 September 2022, or as soon as possible thereafter. Application deadline: 30 June 2022.
The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease
The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is a new Novo Nordisk Foundation funded effort seeking to build comprehensive maps of gene regulation in the human genome for uncovering biological mechanisms on common cardiometabolic diseases. The centre combines recent advances in genomics, molecular biology, single-cell analyses, and stem cell models with approaches in computational biology and machine learning to identify fundamental rules of gene regulation. Susanne Mandrup is one of the Danish partners in this centre.
The Mandrup Group
The Mandrup Group has a long-standing interest in understanding the molecular crosstalk between transcriptional regulation and metabolism in adipocytes and pancreatic β-cells and to understand the molecular basis for the plasticity of cells in the adipose tissue and endocrine pancreas. We also have a long-time interest in the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors. Our laboratory combines genome-wide studies of factor binding, epigenetic marks, and chromatin structure with detailed molecular analyses of the crosstalk between transcriptional regulators. We run an inhouse sequencing platform including single cell sequencing and bioinformatic pipeline.
Susanne Mandrup is Director of Center of Excellence in Functional Genomics and Tissue Plasticity (ATLAS) and Center of Adipocyte Signaling (ADIPOSIGN).
Research project and environment
The project will investigate genome-wide functional and mechanistic aspects of transcriptional regulation in adipocytes. We will uncover basic mechanisms of regulatory elements in the genome in human adipocytes and during human adipocyte differentiation with the aim of linking all regulatory elements to their target promoters. Furthermore, we will determine how specific genome variants affect transcriptional regulation and phenotype of human adipocytes.
The project will be carried out in close collaboration with the group of Dr Melina Claussnitzer at the Broad Institute, and the postdoctoral fellow will benefit from the resources and training facilities at the Broad Institute. The work place will primarily be the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU, but the postdoctoral fellowship, may also involve research exchange to the Broad Institute.
The Functional Genomics & Metabolism Research Unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Postdoc qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
We offer:
For further information please contact Professor Susanne Mandrup ([email protected]).
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease
The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is a new Novo Nordisk Foundation funded effort seeking to build comprehensive maps of gene regulation in the human genome for uncovering biological mechanisms on common cardiometabolic diseases. The centre combines recent advances in genomics, molecular biology, single-cell analyses, and stem cell models with approaches in computational biology and machine learning to identify fundamental rules of gene regulation. Susanne Mandrup is one of the Danish partners in this centre.
The Mandrup Group
The Mandrup Group has a long-standing interest in understanding the molecular crosstalk between transcriptional regulation and metabolism in adipocytes and pancreatic β-cells and to understand the molecular basis for the plasticity of cells in the adipose tissue and endocrine pancreas. We also have a long-time interest in the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors. Our laboratory combines genome-wide studies of factor binding, epigenetic marks, and chromatin structure with detailed molecular analyses of the crosstalk between transcriptional regulators. We run an inhouse sequencing platform including single cell sequencing and bioinformatic pipeline.
Susanne Mandrup is Director of Center of Excellence in Functional Genomics and Tissue Plasticity (ATLAS) and Center of Adipocyte Signaling (ADIPOSIGN).
Research project and environment
The project will investigate genome-wide functional and mechanistic aspects of transcriptional regulation in adipocytes. We will uncover basic mechanisms of regulatory elements in the genome in human adipocytes and during human adipocyte differentiation with the aim of linking all regulatory elements to their target promoters. Furthermore, we will determine how specific genome variants affect transcriptional regulation and phenotype of human adipocytes.
The project will be carried out in close collaboration with the group of Dr Melina Claussnitzer at the Broad Institute, and the postdoctoral fellow will benefit from the resources and training facilities at the Broad Institute. The work place will primarily be the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU, but the postdoctoral fellowship, may also involve research exchange to the Broad Institute.
The Functional Genomics & Metabolism Research Unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Postdoc qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
- A PhD degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Biology.
- Experience with cell biology or NGS data analysis. Competence in transcriptional regulation would be an advantage.
- Strong communication and collaborative skills and a desire to work in an interdisciplinary environment.
- Proficiency in spoken and written English.
We offer:
- A three-year postdoc position in a stimulating and supportive, international research environment with the possibility of extension.
- Access to resources and training facilities at the Broad Institute.
- Training in a wide range of skills including leadership, research management, communication, networking, presentations, writing of grants and manuscripts etc..
- Mentoring and career development.
- Access to state-of-the-art equipment, facilities, and infrastructure.
- Opportunity to interact with an extensive network of national and international collaborators.
- A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.).
- Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor Susanne Mandrup ([email protected]).
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 31.5.2022, men kan have været deaktiveret og genaktiveret igen.
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