Postdoctoral Position in Molecular Microbiology and Chemical-genetic Screening
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Odense M
At the Department of Biochemistry and Molecular Biology we are seeking a motivated and independent postdoctoral candidate with a keen interest in bacterial stress responses and/or high-throughput chemical screening methods for a two-year position in the group of Associate Professor Clare Kirkpatrick. The position should start on 1 August 2023, or as soon as possible thereafter (open for negotiation).
The position is available as part of a Carlsbergfondet Young Researcher Fellowship on signal-jamming approaches to counteract environmental sensing two-component systems in bacteria. The project will focus on chemical-genetic screening of compound libraries for small molecules which interfere with signalling through the two-component system ChvIG in Caulobacter crescentus and eventually in other alpha-proteobacteria.
The successful candidate will take charge of chemical library choice, screen design and execution, validation and follow-up investigation of selected hits and their molecular mechanism of action. We anticipate that in the long term this project will open new lines of investigation into anti-virulence (rather than classical antimicrobial) strategies for combating pathogenic bacteria, by blocking signals which allow them to perceive the presence of host cells and initiate virulence gene expression.
The group is part of the Research Unit for Molecular Microbiology which offers a collaborative and international research environment with fully equipped shared laboratories including our own chemical screening platform. Opportunities to participate in undergraduate teaching, and co-supervise undergraduate or Master-level projects, are also available.
Essential skills and experience:
Desirable skills and experience:
For more information, contact Associate Professor Clare Kirkpatrick, [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
•A copy of one of the candidate’s manuscripts or publications that they consider to be their most significant scientific contribution.
• A statement on why they consider that manuscript/publication to be their most significant scientific contribution (not to exceed 250 words).
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
The position is available as part of a Carlsbergfondet Young Researcher Fellowship on signal-jamming approaches to counteract environmental sensing two-component systems in bacteria. The project will focus on chemical-genetic screening of compound libraries for small molecules which interfere with signalling through the two-component system ChvIG in Caulobacter crescentus and eventually in other alpha-proteobacteria.
The successful candidate will take charge of chemical library choice, screen design and execution, validation and follow-up investigation of selected hits and their molecular mechanism of action. We anticipate that in the long term this project will open new lines of investigation into anti-virulence (rather than classical antimicrobial) strategies for combating pathogenic bacteria, by blocking signals which allow them to perceive the presence of host cells and initiate virulence gene expression.
The group is part of the Research Unit for Molecular Microbiology which offers a collaborative and international research environment with fully equipped shared laboratories including our own chemical screening platform. Opportunities to participate in undergraduate teaching, and co-supervise undergraduate or Master-level projects, are also available.
Essential skills and experience:
- A PhD degree in Molecular Biology, Microbiology, Biochemistry, Genetics or a related field, or should complete the PhD before 1 October 2023. If the PhD degree has not yet been obtained, it must be completed before the start date of the project.
- Experimental experience with bacterial molecular genetics techniques, (eg. molecular cloning, construction of over-expression or knockout bacterial strains, gene expression analysis by promoter-reporter assay, q-RT-PCR).
- High intrinsic motivation and capacity for independent work.
- Excellent scientific communication skills.
- Proficiency in spoken and written English.
Desirable skills and experience:
- Experimental experience with high-throughput chemical screening, particularly phenotype-based screens in bacteria or other cell types.
- Experimental experience with fluorescence or confocal imaging.
- Experience in working with NGS sequence data (eg. genome resequencing, RNA-Seq).
For more information, contact Associate Professor Clare Kirkpatrick, [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
•A copy of one of the candidate’s manuscripts or publications that they consider to be their most significant scientific contribution.
• A statement on why they consider that manuscript/publication to be their most significant scientific contribution (not to exceed 250 words).
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 27.1.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Tirsdag den 28. februar 2023
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