InPharma Open PhD Position - Specific Second Call

Optimising drug co-crystal formulation using in vitro dissolution/permeation models

Host: Solvias AG (Switzerland) & University of Southern Denmark, (SDU), Denmark

PhD awarding institution: Department of Physics, Chemistry and Pharmacy, SDU.

The project will address co-crystals as one means to develop drug candidates including modelling approaches for a thorough prediction of properties as well as innovative bio-predictive tools.

Scientific objectives: : 1) Assess the relationship between APIs and potential partners in generating co-crystals. 2) Develop computational models to predict solvation and intermolecular interaction between drug and co-crystal partners. 3) Assess performance of co-crystals using novel dissolution and permeation models. Industrial aspects: Develop a high throughput screening (HTS) tool to rank co-crystal formulation approaches in early stage drug development.

Requirements
The applicant must:

• Have a Master’s degree (or any equivalent diploma) in relevant area (e.g. Pharmacy, Pharmaceutical Sciences, Physical Chemistry, Drug Delivery or Industrial Pharmacy; candidates with strong backgrounds/experience in project-specific scientific fields such as Physical Chemistry, Chemical Engineering, and/or Mathematics/modelling may also be considered).
• Practical hands-on experience with small scale preparation and characterization of solid states, preferably including cocrystals, is a prerequisite, and additional hands-on experience with advanced in vitro biopharmaceutical methods like dissolution/permeation studies is desired.
• Should be — at the date of recruitment — an ‘early stage researcher (ESR)’, i.e. in the first four years (full-time equivalent) of his/her research career and must not have a PhD doctoral degree. This is measured from the date when they obtained the degree which would formally entitle them to embark on a doctorate, either in the country which the degree was obtained or in the country in which the research training is provided.
• Satisfy MSCA rules for transnational mobility: The applicant should not have resided in the country where the research training activities take place for more than 12 months in the three years immediately prior to the recruitment date and not have carried out their main activity (work, studies, etc.) in that country.
• Have solid written and oral communication skills in English as communication and teaching language throughout InPharma is English. Candidates who are not fluent in English are requested to provide proof of English proficiency (in speaking and writing) (e.g. typically IELTS min. 7, TOEFL internet-based min. 90 or similar level as proven by other tests).

This position is subject to the entry into force of grant agreement no 955756 by and funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie.

Deadline: 15 August 2021.

Please see the complete call, including how to apply, on www.sdu.dk.

Kilde: Jobnet.dk