Senior/Principal Analytical Technician
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A chance to be part of an ambiguous and flexible laboratory group in LEO CMC area
LEO Pharma has embarked on a growth journey to become the preferred dermatology care partner in the world, dedicated to help people achieve healthy skin. We have an ambitious 2030 strategy, which aims to accelerate our impact in protein-based therapeutics while strengthening our established portfolio and our global footprint in medical dermatology. Dermatology is an area of rapid growth and LEO Pharma´s vision is to help people with mild, moderate, and severe dermatological diseases across the world. To meet the requirements of an increasing pipeline of biologics projects we are now expanding in the CMC biologics area both in terms of capabilities and capacity. This is why we need you!
The job
Your overall focus will be screening, characterization, and analysis of monoclonal antibodies (mAbs) and bispecific antibodies (BsAbs) in close collaboration with formulation and analytical scientists to support our early phase lab activities. You will be responsible for sample preparation, developing analytical methods, maintaining analytical equipment, write analytical procedures, data analysis of your own experiments and documenting the data and results in ELN. You will be working with the team to deliver high quality results for the projects in early phase development, and you will also work with colleagues from the bioprocess and formulation departments.
Your primary tasks will be:
- MS analyses for characterisation of antibodies ((intact protein, sub-unit, charge variant, and peptide mapping) on Orbitrap high resolution MS equipment by LC-MS and CE-MS.
- Daily maintenance of LC-MS and CE-MS equipment.
- Ad hoc MS tasks and troubleshooting for proteins from R&D as such.
- Data analyses with MS deconvolution software from Thermo and Protein metrics.
- Periodically CIEX, CIEF, SEC, SEC-MALS or CE-SDS analyses of antibodies.
- Method development, forced degradation studies and developability assessment of variants
- Handling of large number of protein samples for screening studies and developability assessment of mAb candidate
- Setting up and conducting protein stability studies including several analytical methods.
- Maintain a balance between experimental work and solid documentation of work and data
- Take part in troubleshooting using the joined analytical knowledge of the early phase group
As we are breaking new ground and are part of an R&D organization, no two days are alike. As such, you must be able to thrive in a dynamic R&D environment and have the drive and entrepreneurial spirit to move things ahead.
Your qualifications
You have an education as Laboratory Technician or similar with at least 5 years’ experience in protein analysis and characterization and at least 2 years of experience working with LC-MS. Your career has provided you with hands-on experience within development of analytical methods for mAbs or other proteins as well as with experience with solving day-to-day tasks within the laboratory. You have worked with and have an interest for new technologies in the analytical area and have a flair for equipment and problem solving.
You are curious by nature and like to try new things, methods, processes etc. You combine strong bench skills with a good sense for documentation to ensure the right quality in your deliverables. As you will work together with multiple people across the LEO organization, good collaboration skills are of great importance.
Your new team
You will join a team of thirteen (today) skilled colleagues covering early phase biopharmaceutical competencies. We are a growing team, and our focus is to support selection of stable mAbs and development of stabilizing formulations for LEO Pharma’s portfolio of biologics. We aim to establish an innovation culture characterized by openness, plenty of room for new ideas, mutual respect and helpfulness – while not forgetting to have a good time together. The department is part of Biologicals CMC Development consisting of 30+ highly skilled and dedicated colleagues striving to deliver high quality science to progress our Research and Development projects and to deliver innovative products to patients.
We are here to take ownership, drive, and secure that scientific questions are both raised and answered within Biologics. We are driven by a high level of integrity, science, passion for our work and an open minded, collaborative approach.
Join our mission to help more people achieve healthy skin
Hundreds of millions of people around the globe are suffering from an untreated skin disease. Helping these people to get a better life is what LEO Pharma is all about. By understanding their needs and wishes we will improve existing treatments and break new land to uncover the solutions of tomorrow.
By joining LEO Pharma you will get the opportunity to create results, develop yourself among highly skilled colleagues while taking on our quest to become the preferred dermatology care partner improving people’s lives around the world and at the same time create profitable growth.
Contact and application
We look forward to receiving your application in English or Danish not later than 15th of April 2022. 2021. If you need further information please contact Christer Andersson, Senior Manager of Biopharmaceutical Analytical Development (+45 31 38 59 86) or Lars Dencker, Principal Analytical Scientist (+45 22 35 45 82) or Ina Dosen, Senior Scientist (+45 21 77 72 69).
About LEO Pharma
LEO Pharma helps people achieve healthy skin. By offering care solutions to patients in more than 100 countries globally, LEO Pharma supports people in managing their skin conditions. Founded in 1908 and owned by the LEO Foundation, the healthcare company has devoted decades of research and development to delivering products and solutions to people with skin conditions. LEO Pharma is headquartered in Denmark and employs around 6,000 people worldwide. For more information, visit www.leo-pharma.com.
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i Ballerup.
Jobbet er oprettet på vores service den 22.3.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- Ballerup
- Fredag den 15. april 2022
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