Master Thesis
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Master thesis project: Development of alternative analytical methods for quantification of excipients
Formulations of protein-based pharmaceuticals often include surfactants to help stabilizing the proteins and maintaining their functionality. Examples are PS20, PS80, PX188 and FM1000. During development and production of protein-based pharmaceuticals it is important to quantify the content of protein as well as excipient. However, separation between these surface-active excipients (surfactants) and the protein can be challenging and lead to misleading analysis results.
At present, chromatographic methods with different separation principles are used, e.g. reverse-phase (RP) and size-exclusion (SE). These are combined with different detection principles, e.g. CAD, QDa/MS. In this project, alternative methods for quantitative determination of excipients will be explored and tested. This may include further development of existing chromatographic methods as well as combining chromatographic methods with new analysis principles.
Project scope
• Development of methods for quantitative determination of excipients such as surfactants that help stabilizing the proteins and maintaining their functionality.
• Explore chromatographic methods with different separation principles, e.g. reverse-phase (RP) and size-exclusion (SE), combined with different detection principles, e.g. CAD, QDa/MS for excipient analysis.
• Establishment of a method by which excipients can be robustly quantified Desired skills/compentencies
• Solid knowledge within chemical analysis, preferably chromatography
• Interest in biophysics and surface chemistry
• Practical laboratory skills How to apply
Please send your application no later than 25 October 2024. Your CV is not required, and the application must not exceed more than ½ page and must contain:
• A short description of who you are as a person
• How you would solve the project
• Your motivation to write your thesis on an analytical topic
• Project start date and the possibility of combining with a pre-project Contact For further information, don't hesitate to contact Specialist, Liselotte Kold at +. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Formulations of protein-based pharmaceuticals often include surfactants to help stabilizing the proteins and maintaining their functionality. Examples are PS20, PS80, PX188 and FM1000. During development and production of protein-based pharmaceuticals it is important to quantify the content of protein as well as excipient. However, separation between these surface-active excipients (surfactants) and the protein can be challenging and lead to misleading analysis results.
At present, chromatographic methods with different separation principles are used, e.g. reverse-phase (RP) and size-exclusion (SE). These are combined with different detection principles, e.g. CAD, QDa/MS. In this project, alternative methods for quantitative determination of excipients will be explored and tested. This may include further development of existing chromatographic methods as well as combining chromatographic methods with new analysis principles.
Project scope
• Development of methods for quantitative determination of excipients such as surfactants that help stabilizing the proteins and maintaining their functionality.
• Explore chromatographic methods with different separation principles, e.g. reverse-phase (RP) and size-exclusion (SE), combined with different detection principles, e.g. CAD, QDa/MS for excipient analysis.
• Establishment of a method by which excipients can be robustly quantified Desired skills/compentencies
• Solid knowledge within chemical analysis, preferably chromatography
• Interest in biophysics and surface chemistry
• Practical laboratory skills How to apply
Please send your application no later than 25 October 2024. Your CV is not required, and the application must not exceed more than ½ page and must contain:
• A short description of who you are as a person
• How you would solve the project
• Your motivation to write your thesis on an analytical topic
• Project start date and the possibility of combining with a pre-project Contact For further information, don't hesitate to contact Specialist, Liselotte Kold at +. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 27.9.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- Måløv
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