PhD Fellowship to study metabolic control of cell cycle in early development mechanism and cancer
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Odense M
At the laboratory of Associate Professor Kumar Somyajit, we seek a highly motivated PhD student with strong background in molecular and cell biology and prime interest in cell cycle, genome maintenance, early development mechanisms, and quantitative imaging. Experience with CRISPR-based gene editing, optical microscopy, and quantitative skills are required. Previous work in the field of metabolism, genome integrity and epigenetics or/and experience in working on embryonic/adult stem cells are a plus.
The Somyajit lab, based at the Functional Genomics & Metabolism Research Unit at Department of Biochemistry and Molecular Biology, SDU, has a deep interest in studying regulatory foundations of the cell cycle, DNA replication, and genome surveillance in pathophysiology.
Application deadline: 16-02-2024.
Starting date: 01-03-2024, or as soon as possible thereafter.
Duration: 3 years as a PhD student funded by the ERC starting grant.
We expect interviews will be held in the last week of Feb 2024.
Research Project and Role
Metabolic fluctuations (such as Redox), together with changes in DNA replication and cell cycle dynamics, balance the self-renewal and differentiation of stem cells during embryonic growth and tissue homeostasis throughout adult life. However, despite their obvious importance in cell physiology, the direct interplay among these major cellular processes still needs to be explored.
As a PhD student in the Somyajit group, you will be engaged in a highly interdisciplinary project uncovering regulatory foundations of core-cell cycle machinery (Cyclin-CDKs) and genome protection in the context of natural metabolic fluctuations during stem cell proliferation and their differentiation.
You will employ CRISPR-based gene editing in mammalian cell models of development (embryonic and adult stem cells) and non-transformed human cells to endogenously label and quantify - Cyclin-CDK activities and subcellular metabolic states. With these novel cell models, you will combine advanced quantitative cell biology approaches such as quantitative-image-based-cytometry- QIBC, time-lapse microscopy, super-resolution microscopy, DNA fiber techniques, RNA sequencing, with classical genetics to reveal foundational mechanistic links between metabolic fluctuations and the Cyclin-CDK activities in embryonic cell division, cell fate determination, cell fitness, and cell survival.
You will interact and collaborate closely with other researchers in the Somyajit and with members of the different research groups within FGM and at the Department of Biochemistry and Molecular Biology.
The Functional Genomics & metabolism Research Unit
The Somyajit group is located in the Functional Genomics & Metabolism Research Unit headed by Prof. Susanne Mandrup at the Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts 8 independent research groups investigating on various aspects of functional genomics, chromatin biology, genome stability and cell cycle, and their interplay in cellular identity, differentiation, metabolism and disease suppression. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for advanced bioimaging, quantitative mechanistic cell biology, next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Qualifications/requirements
We are looking for highly motivated, dedicated, and ambitious candidates with:
For further information please contact Kumar Somyajit ([email protected])
Application deadline: 16 February 2024.
Please see the full call, including how to apply, on www.sdu.dk
Kilde: Jobnet.dk
The Somyajit lab, based at the Functional Genomics & Metabolism Research Unit at Department of Biochemistry and Molecular Biology, SDU, has a deep interest in studying regulatory foundations of the cell cycle, DNA replication, and genome surveillance in pathophysiology.
Application deadline: 16-02-2024.
Starting date: 01-03-2024, or as soon as possible thereafter.
Duration: 3 years as a PhD student funded by the ERC starting grant.
We expect interviews will be held in the last week of Feb 2024.
Research Project and Role
Metabolic fluctuations (such as Redox), together with changes in DNA replication and cell cycle dynamics, balance the self-renewal and differentiation of stem cells during embryonic growth and tissue homeostasis throughout adult life. However, despite their obvious importance in cell physiology, the direct interplay among these major cellular processes still needs to be explored.
As a PhD student in the Somyajit group, you will be engaged in a highly interdisciplinary project uncovering regulatory foundations of core-cell cycle machinery (Cyclin-CDKs) and genome protection in the context of natural metabolic fluctuations during stem cell proliferation and their differentiation.
You will employ CRISPR-based gene editing in mammalian cell models of development (embryonic and adult stem cells) and non-transformed human cells to endogenously label and quantify - Cyclin-CDK activities and subcellular metabolic states. With these novel cell models, you will combine advanced quantitative cell biology approaches such as quantitative-image-based-cytometry- QIBC, time-lapse microscopy, super-resolution microscopy, DNA fiber techniques, RNA sequencing, with classical genetics to reveal foundational mechanistic links between metabolic fluctuations and the Cyclin-CDK activities in embryonic cell division, cell fate determination, cell fitness, and cell survival.
You will interact and collaborate closely with other researchers in the Somyajit and with members of the different research groups within FGM and at the Department of Biochemistry and Molecular Biology.
The Functional Genomics & metabolism Research Unit
The Somyajit group is located in the Functional Genomics & Metabolism Research Unit headed by Prof. Susanne Mandrup at the Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts 8 independent research groups investigating on various aspects of functional genomics, chromatin biology, genome stability and cell cycle, and their interplay in cellular identity, differentiation, metabolism and disease suppression. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for advanced bioimaging, quantitative mechanistic cell biology, next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Qualifications/requirements
We are looking for highly motivated, dedicated, and ambitious candidates with:
- A Master’s degree in Life Science, preferable Molecular Biology, Cell Biology, Biomedicine
- Curious mind-set with a strong interest in fundamental Cell cycle, DNA replication and Genome integrity
- Relevant laboratory experience in molecular cell biology and biochemistry
- Know-how in Genome integrity field, stem cell culture, light microscopy, bioinformatics will be considered an advantage.
- Strong communication and collaborative skills and an interest in working in an interdisciplinary environment.
- Proficiency in spoken and written English
For further information please contact Kumar Somyajit ([email protected])
Application deadline: 16 February 2024.
Please see the full call, including how to apply, on www.sdu.dk
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 25.1.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- Odense M
- Fredag den 16. februar 2024
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