Principal Scientist - Immunology

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Do you want to take part in creating the therapies of the future? We are looking to hire a talented Principal Scientist to help us address the immunology challenges that come with the development of gene-modified cell lines for therapeutic applications. This position is based in the Cell Engineering department within the Cell Therapy R&D unit at Novo Nordisk. If this opportunity aligns with your interests, apply today, and support us in translating stem cell-derived cell therapies into the clinic. The position We are looking for a Principal Scientist who is ready to take on a position to support our efforts to progress stem cell-based therapies towards clinical development, focused primarily on type 1 diabetes, chronic heart failure, and Parkinson’s disease. You will be part of a unique innovative and collaborative culture in Cell Therapy R&D, where you will work as part of a dedicated and supportive team, and with a high degree of autonomy and empowerment in your daily tasks. Your main responsibilities will include:
  • Generating in vitro proof-of-concept data to support the development of genome-modified, hypoimmunogenic allogeneic cell therapy products.

  • Designing, implementing and overseeing of various in vitro and in vivo studies depending on the needs of the project.

  • Investigating methods and technologies for the rapid advancement of projects and performing scientific analyses for results interpretation and presentation.

  • Training, mentorship and supervision of colleagues across all levels.

  • Contributing towards developing the research agenda.

  • Working across various projects and collaboratively to build relationships with wider in-house immunology expertise across Novo Nordisk.

    • Qualifications As a Principal Scientist, you have a PhD degree in Immunology or a related field with 5+ years of relevant post-doctorate or industry experience. You have deep knowledge of human immunology including the alloimmune terrain and immunologic responses to allogeneic cell delivery and engraftment. To succeed in this position you have:
  • Preferably an understanding of Diabetes disease biology.

  • Demonstrated experience in designing and conducting experiments involving state of the art techniques within the areas of immunology, biochemistry and molecular biology.

  • Documented experience in the development and optimization of cellular immunology co-culture assays (incl. immune cell and complement cytotoxicity or phagocytosis assays).

  • Experience with flow cytometry, live cell imaging (Incucyte, xCelligence), cytokine assays (ELISA/MSD) and RT-qPCR.

  • Experience with antibody/bead-based cell selection systems (FACS/MACS).

  • Experience with mouse models for human cell therapy engraftment studies and working with primary human blood samples.

    • On a personal level, you are dedicated, hard-working, and dependable with strong communication, writing, and data presentation skills. You have excellent leadership, communication, interpersonal and problem-solving skills. In addition, you have the ability to work in a team-oriented and multidisciplinary environment. About the department The Department of Cell Engineering is a dynamic, technology driven department, part of Cell Therapy R&D, a Transformational Research Unit (TRU) within Novo Nordisk. The TRU is unique in the sense that it covers the full R&D value chain, which means we function as an integrated unit, spanning from early research to GMP manufacturing and clinical development in the same organisation. Our department is part of the Research organization based in Måløv, Denmark and we are experts in stem cell culture, genome editing, differentiation, characterization, and both in vitro and in vivo functional assessment. Working at Novo Nordisk At Novo Nordisk, we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing and sales – we’re all working to move the needle on patient care. Contact For further information, please contact Tristan Thwaites, Director at [email protected] . Deadline 10 November 2023 Applications will be reviewed on an ongoing basis, so we encourage you to apply as soon as possible. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo to your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.


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    Denne ledige stilling har jobtypen "Forretningsudvikler", og befinder sig i kategorien "Kommunikation, marketing, salg".

    Arbejdsstedet er beliggende i Måløv.

    Jobbet er oprettet på vores service den 20.10.2023, men kan have været deaktiveret og genaktiveret igen.

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