We are looking for a highly motivated and dynamic postdoc for a 2 year position, to commence 1 September 2024.

About the groups

The Choudhary lab is technically and internationally diverse and embedded in an excellent environment that supports high-quality research and encourages interdisciplinary collaboration. The Choudhary lab conducts research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR-based genome editing, and bioinformatics. The lab uses diverse cell models, including embryonic stem cells and their differentiated derivatives.

The group extensively collaborates with top-level international researchers, routinely publishes in top-ranked journals, and has an outstanding track record in training the next generation of researchers. The major publications from the groups include Narita et al. https://www.biorxiv.org/content/10.1101/2022.07.18.500456v2, Prus et al. Cell 2024, Narita et al. Nat. Genet. 2023, Narita et al. Mol Cell. 2021, Narita et al. Nat Rev Mol Cell Biol 2019, Weinert and Narita et al. Cell 2018, Gupta et al. Cell 2018, Scholz et al. Nat Biotech 2015, Weinert et al., Mol Cell 2013, Povlsen and Beli et al. Nat Cell Biol 2012, and Beli et al. Mol Cell 2012.

We are now looking for enthusiastic postdocs with a PhD and/or MD (i.e. level of education corresponding to the Danish PhD degree).

Project description

Our group works in the broad area of proteomics, genomics, and cell signaling. Recently, group identified histone H2BNTac as a new signature of bona fide enhancers (Narita et al. Nat Genet 2023). In the envisioned projects, we aim to use quantitative proteomics to further uncover the proteome-wide scope, dynamics, and enzymatic regulation of lysine acetylation and ubiquitylation. We are also interested in combining CRISPR-based genome editing with NGS-based approaches (i.e. RNA-seq, ChIP-seq, ATAC-seq) and cell biological approaches to uncover new regulatory pathways and decipher underlying mechanisms. In particular, we are interested in understanding the scope and function of lysine acetylation in gene regulation, as well as to understand the mechanisms of gene activation by cis-regulatory enhancers.

Depending on the candidate´s background, the postdoc candidate will either perform wet laboratory experiments involving cultured mammalian cells, CRISPR, and NGS-based genomic technologies, or proteomics technologies to generate large-scale datasets and to understand cellular regulatory mechanisms. Candidate with interest in data analysis is expected to perform bioinformatic analyses of next-generation sequencing data, including ChIP-seq, RNA-seq, Nascent-seq, and ATAC-seq. The candidates with experience in both wet lab and bioinformatics will be able to do both (i.e. work in the wet lab and perform bioinformatics analyses). If you would like to know more about the project(s), please contact us!

The postdoc positions are funded by long-term project funding by Novo Nordisk Foundation Distinguished Investigator grant (grant period 2022- mid 2027), and ERC advanced grant (Oct 2024- Sept. 2029).

Tentative start date: September 2024 or later. The start date can be negotiated.

Profile
The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good interpersonal and communication skills.

• The candidate is required to have a PhD/MD level of education corresponding to the Danish PhD degree in natural or medical science.
• Excellent scientific track record, including at least one publication in a high-quality, peer-reviewed international journal. Pre-prints can be counted for fulfilling this requirement.
• Expert knowledge in one or more of the following areas is advantageous:
  • Prior experience in the area of epigenetics, and gene transcription regulation.
  • Hands-on experience in generating datasets for ChIP-seq, RNA-seq, ATAC-seq
  • Hands-on experience in quantitative mass spectrometry for analyzing proteins, their modifications, and protein-protein interactions
  • Hands-on experience in bioinformatic analyzing next-generation sequencing datasets, such as ChIP-seq, RNA-seq, ATAC-seq
  • Experience in computer programming languages, such as R, Python
  • Strong background in the statistical analysis of large-scale data
  • Experience in molecular biology techniques, including proficient use of CRISPR-based genome editing
  
  
• Good communication skills, both oral and written.
• An analytical aptitude for devising innovative scientific or technical solutions.

Place of employment

The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. In the past 10 years, CPR has established itself as a top-level research institute in protein signaling and network biology research. The research environment at CPR is ambitious and international, with approx. 30 different nationalities are currently represented. The Center comprises modern laboratories, supercomputer resources, and state-of-the-art research facilities. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center. Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk

Terms of employment
The average weekly working hours are 37 hours per week.

The position is a fixed-term position limited to a period of 2 years. The starting date is 1 September 2024

Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 38,575.98 DKK/approx. 5,100 EUR (April 2024 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Questions
For further information, please contact Professor Chunaram Choudhary, email: [email protected] www.sund.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.

Deadline for applications: 14 June 2024, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 27.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

Kilde: Jobnet.dk