Postdoc in Single Cell Proteomics Technology and Chromatin Biology
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Odense M
The Protein Research Group (Professor Ole N. Jensen) at the Department of Biochemistry and Molecular Biology at the University of Southern Denmark (SDU) in Odense invites applications for a postdoctoral research position in single cell proteomics and chromatin biology for up to three years.
The research project aims to elucidate molecular mechanisms of chromatin regulation in the context of cancer. It entails the development and application of single cell proteomics and mass spectrometry technologies for studies of epigenetic and transcriptional regulation of chromatin. The main focus will be on the development of high-sensitivity bioanalytical technologies for isolation and detailed characterization of chromatin binding proteins, including histones and their post-translational modifications.
You will be part of an international and dynamic research team. You will be motivated to use capillary liquid chromatography, mass spectrometry and computational tools and develop new approaches to investigate regulatory events in chromatin biology at the single cell level. You will be responsible for implementing mass spectrometry based technologies for high-sensitivity quantitative studies of proteins and their dynamic post-translational modifications. You will manage independent research projects and assist in the supervision of undergraduate and graduate students.
The position is to be filled by 1 March 2021 or soon thereafter. Application deadline: 20 January 2021.
Qualifications
We are looking for a highly motivated, competent and enthusiastic scientist with excellent communication skills.
For consideration, applicants must have:
In addition, applicants with one or more of the following types of experience will be preferred:
Strong research and training environment
The Jensen laboratory is part of the Protein Research Group and offers an open international collaborative research environment in protein chemistry, biomolecular mass spectrometry, and computational proteomics. Our main focus is the elucidation of the functional roles of dynamic post-translational modifications of proteins. The VILLUM Center for Bioanalytical Sciences at SDU and the national PRO-MS research infrastructure provides world-class facilities for quantitative proteomics and mass spectrometry research, including a suite of Orbitrap mass spectrometers (Eclipse, Lumos, Exploris 480).
Recent publications on mass spectrometry, proteomics and chromatin biology by the ON Jensen group include Shliaha et al (2020) Anal. Chem. 92(3) 2364.2368; Radzisheuskaya et al (2019) Nat. Struct. Mol. Biol. (26)11 999-1012; Tvardovskiy et al (2017) Nucleic Acids Res. 45(16):9272-9289.
Place of work
Protein Research Group (Professor Ole N. Jensen), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense. Contact: [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must be made in the form of a short Declaration of Interest and must include the following documents:
• Letter of motivation, including details on qualifications and experience within subject area (max. one page).
• A curriculum vitae including information on previous employment, list of experimental and computational skills mastered by the applicant, and teaching and supervision experience.
• A full list of publications stating the scientific publication(s) on which the applicant wishes to rely.
• Two letters of recommendation from supervisors or previous employers. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
The research project aims to elucidate molecular mechanisms of chromatin regulation in the context of cancer. It entails the development and application of single cell proteomics and mass spectrometry technologies for studies of epigenetic and transcriptional regulation of chromatin. The main focus will be on the development of high-sensitivity bioanalytical technologies for isolation and detailed characterization of chromatin binding proteins, including histones and their post-translational modifications.
You will be part of an international and dynamic research team. You will be motivated to use capillary liquid chromatography, mass spectrometry and computational tools and develop new approaches to investigate regulatory events in chromatin biology at the single cell level. You will be responsible for implementing mass spectrometry based technologies for high-sensitivity quantitative studies of proteins and their dynamic post-translational modifications. You will manage independent research projects and assist in the supervision of undergraduate and graduate students.
The position is to be filled by 1 March 2021 or soon thereafter. Application deadline: 20 January 2021.
Qualifications
We are looking for a highly motivated, competent and enthusiastic scientist with excellent communication skills.
For consideration, applicants must have:
- A recent PhD degree in biochemistry, protein science/proteomics, analytical biochemistry or a similar field
- Demonstrated experience in experimental protein biochemistry and mass spectrometry
- Interest in the study of bioanalytical technologies and their applications in chromatin biology
- Publications in high-quality international peer-reviewed journals
- Excellent English speaking, reading and writing skills.
In addition, applicants with one or more of the following types of experience will be preferred:
- Working experience with nanoliter flow LC-MS/MS using Orbitrap or Q-TOF instruments
- Experience with biochemical characterization of chromatin and the chromatin proteome
- Advanced knowledge of physical chemistry and bioanalytical instruments
- Computational proteomics and data analysis, including R scripting.
Strong research and training environment
The Jensen laboratory is part of the Protein Research Group and offers an open international collaborative research environment in protein chemistry, biomolecular mass spectrometry, and computational proteomics. Our main focus is the elucidation of the functional roles of dynamic post-translational modifications of proteins. The VILLUM Center for Bioanalytical Sciences at SDU and the national PRO-MS research infrastructure provides world-class facilities for quantitative proteomics and mass spectrometry research, including a suite of Orbitrap mass spectrometers (Eclipse, Lumos, Exploris 480).
Recent publications on mass spectrometry, proteomics and chromatin biology by the ON Jensen group include Shliaha et al (2020) Anal. Chem. 92(3) 2364.2368; Radzisheuskaya et al (2019) Nat. Struct. Mol. Biol. (26)11 999-1012; Tvardovskiy et al (2017) Nucleic Acids Res. 45(16):9272-9289.
Place of work
Protein Research Group (Professor Ole N. Jensen), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense. Contact: [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must be made in the form of a short Declaration of Interest and must include the following documents:
• Letter of motivation, including details on qualifications and experience within subject area (max. one page).
• A curriculum vitae including information on previous employment, list of experimental and computational skills mastered by the applicant, and teaching and supervision experience.
• A full list of publications stating the scientific publication(s) on which the applicant wishes to rely.
• Two letters of recommendation from supervisors or previous employers. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 10.12.2020, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Onsdag den 20. januar 2021
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