Postdoctoral Positions to Study Mechanisms of Adipocyte Lineage Determination
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Odense M
The Mandrup group at the Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested in joining our group as postdoctoral scientist. The position is available from 1 April 2022 or as soon as possible thereafter. Application deadline: 1 March 2022.
Research project
The ability of higher eukaryotic cells to control transcription is a prerequisite for specialization during development, and for maintenance as well as plasticity of cellular identity. It is becoming increasingly clear that this important regulation is dependent on physical compartmentalization of the genome into functional units and on elaborate cooperativity between transcription factors within these units. Understanding the interplay between chromatin topology and transcriptional activity constitutes one of major current challenges in the transcription field. We have recently applied enhancer capture Hi-C to investigate enhancer interactions in human mesenchymal stromal cells (MSCs) undergoing adipocyte differentiation. We showed that enhancers form highly interconnected enhancer communities that appear to act as hubs driving adipocyte lineage determination.
In this project, which builds on extensive published and unpublished data from the Mandrup laboratory, we will investigate the interplay between chromatin topology and transcriptional regulation during adipocyte differentiation. These data are expected to have important implications for the understanding of transcriptional regulation in general.
The Functional Genomics & Metabolism Research Unit
The Mandrup Group is located in the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation, and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
We offer:
For further information please contact Professor Susanne Mandrup at [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Research project
The ability of higher eukaryotic cells to control transcription is a prerequisite for specialization during development, and for maintenance as well as plasticity of cellular identity. It is becoming increasingly clear that this important regulation is dependent on physical compartmentalization of the genome into functional units and on elaborate cooperativity between transcription factors within these units. Understanding the interplay between chromatin topology and transcriptional activity constitutes one of major current challenges in the transcription field. We have recently applied enhancer capture Hi-C to investigate enhancer interactions in human mesenchymal stromal cells (MSCs) undergoing adipocyte differentiation. We showed that enhancers form highly interconnected enhancer communities that appear to act as hubs driving adipocyte lineage determination.
In this project, which builds on extensive published and unpublished data from the Mandrup laboratory, we will investigate the interplay between chromatin topology and transcriptional regulation during adipocyte differentiation. These data are expected to have important implications for the understanding of transcriptional regulation in general.
The Functional Genomics & Metabolism Research Unit
The Mandrup Group is located in the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation, and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
Qualifications/requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:
- A PhD degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Biology
- Experience with research in the field of transcriptional regulation
- Documented experience with cell biology and NGS data analysis
- At least one first-author publication in a relevant journal in the field
- Strong communication and collaborative skills and a desire to work in an interdisciplinary environment
- Proficiency in spoken and written English.
We offer:
- A three-year postdoc position in a stimulating and supportive, international research environment
- Access to state-of-the-art equipment, facilities, and infrastructure
- Opportunity to interact with an extensive network of national and international collaborators
- A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
- Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor Susanne Mandrup at [email protected].
Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The application must include the following:
• A curriculum vitae including information on previous employment.
• A full list of publications stating the scientific publications on which the applicant wishes to rely.
Shortlisting may be used in the assessment process.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated.
To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 21.12.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Tirsdag den 01. marts 2022
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