PhD Scholarship to Study Enhancers Communities in Lineage Determination of Stem Cells
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Odense M
The Mandrup group at the Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested in joining our group as a PhD student. The position is available from 1 September 2022, or as soon as possible thereafter. Application deadline: 8 August 2022.
Research project
The ability of higher eukaryotic cells to control transcription is a prerequisite for specialization during development, and for maintenance as well as plasticity of cellular identity. It is becoming increasingly clear that this important regulation is dependent on physical compartmentalization of the genome into functional units and on elaborate cooperativity between transcription factors within these units. Understanding the interplay between chromatin topology and transcriptional activity constitutes one of the major current challenges in the transcription field.
We have recently applied enhancer capture Hi-C to investigate enhancer interactions in human mesenchymal stromal cells (MSCs) undergoing adipocyte differentiation. We showed that enhancers form highly interconnected enhancer communities that appear to act as hubs driving adipocyte lineage determination. Ongoing work in our group now focuses on delineating the interplay between chromatin topology and transcriptional regulation during adipocyte differentiation.
The PhD fellow will drive functional genomics studies in human mesenchymal stem cells to identify key regulatory enhancers and architectural proteins, and to define basic mechanisms of enhancer function and crosstalk during adipocyte differentiation. The fellow will work closely together with a postdoc and another PhD student on the project. The project can involve research exchange to collaborating laboratories including those within ENHPATHY, if in the interest of the student.
The Functional Genomics & Metabolism Research Unit
The Mandrup Group are located in the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation, and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
PhD qualifications/requirements
We are looking for highly motivated, dedicated, and ambitious candidates with:
We offer:
For further information please contact Professor Susanne Mandrup, tel.: +45 6550 2340, e-mail: [email protected].
Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box "Application form")
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Further information for international applicants about entering and working in Denmark.
Research project
The ability of higher eukaryotic cells to control transcription is a prerequisite for specialization during development, and for maintenance as well as plasticity of cellular identity. It is becoming increasingly clear that this important regulation is dependent on physical compartmentalization of the genome into functional units and on elaborate cooperativity between transcription factors within these units. Understanding the interplay between chromatin topology and transcriptional activity constitutes one of the major current challenges in the transcription field.
We have recently applied enhancer capture Hi-C to investigate enhancer interactions in human mesenchymal stromal cells (MSCs) undergoing adipocyte differentiation. We showed that enhancers form highly interconnected enhancer communities that appear to act as hubs driving adipocyte lineage determination. Ongoing work in our group now focuses on delineating the interplay between chromatin topology and transcriptional regulation during adipocyte differentiation.
The PhD fellow will drive functional genomics studies in human mesenchymal stem cells to identify key regulatory enhancers and architectural proteins, and to define basic mechanisms of enhancer function and crosstalk during adipocyte differentiation. The fellow will work closely together with a postdoc and another PhD student on the project. The project can involve research exchange to collaborating laboratories including those within ENHPATHY, if in the interest of the student.
The Functional Genomics & Metabolism Research Unit
The Mandrup Group are located in the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts seven independent research groups focusing on various aspects of gene regulatory mechanisms controlling cellular identity, differentiation, and metabolism. The research unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).
PhD qualifications/requirements
We are looking for highly motivated, dedicated, and ambitious candidates with:
- A Master’s degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Systems Biology. The degree must be completed by the start of the PhD scholaship.
- Experience with cell biology or NGS data analysis. Knowledge about transcriptional regulation would be an advantage.
- Strong communication and collaborative skills and an interest in working in an interdisciplinary environment.
- Proficiency in spoken and written English.
We offer:
- A three-year PhD position in a highly stimulating, supportive, international, and interdisciplinary research environment.
- Enrolment in the PhD school of Biochemistry and Molecular Biology, which allows the candidate to tailor a flexible individualized course programme.
- Training in a wide range of skills including research management, communication, networking, presentations, writing of manuscripts etc..
- Research exchange to collaborating institution, depending on the interest of the PhD student.
- Mentoring and career development.
- Access to state-of-the-art equipment, facilities, and infrastructure.
- Opportunity to interact with an extensive network of national and international collaborators.
- A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.).
- Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor Susanne Mandrup, tel.: +45 6550 2340, e-mail: [email protected].
Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Application must be made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box "Application form")
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: [email protected] mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.
Shortlisting may be used in the assessment process.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Further information for international applicants about entering and working in Denmark.
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 24.6.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Mandag den 08. august 2022
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