Postdoc for the Molecular Bone Histology Laboratory
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Odense M
A full-time postdoc position is vacant at the Molecular Bone Histology Laboratory (MBH lab) at the Research Unit of Pathology, Department of Clinical Research, SDU.
The 4-year position is open from January 1, 2024, or as soon as possible thereafter and will be agreed with the successful candidate.
The MBH labis headed by Associate Professor Thomas Levin Andersen with the overarching aim of facilitating a better understanding of bone and bone diseases, including osteoporosis and its treatment.
The MBH lab within the Research Unit of Pathology hosts the Danish Spatial Imaging Consortium (DanSIC) utilizing the newest technologies within molecular spatial histology, allowing detailed transcriptomic analysis while maintaining the spatial context. The MBH lab is part of a hot spot in Danish bone research with six neighboring teams including +40 scientists, technicians and students all focusing on different aspects of bone research.
The open postdoc position is funded by a multi-PI NIH R01 grant (1R01AR080118-01A1) in collaboration with Dr. Ryan Ross from the Rush University Medical Center, Chicago, US, and Dr. Joseph Wallace, Indiana University, Indianapolis, US. The project is entitled: "How bisphosphonates affect bone matrix and remodeling: implications for atypical femoral fractures".
Atypical femoral fractures (AFFs) are a rare but devastating side effect of long-term bisphosphonate (BP) treatment. Despite the relatively low prevalence of AFFs, public awareness has considerably depressed osteoporosis medication adherence. The mechanisms driving BP associated AFFs remain elusive and several mechanisms have been proposed, including impaired bone remodeling, altered bone matrix maturation, and the accumulation of tissue microdamage. A critical barrier to understanding how BPs negatively affect skeletal integrity is the difficulty in separating the individual contributions of altered remodeling kinetics (suppressed resorption and formation) from bone matrix maturation. We will overcome this barrier with our recently validated rat model of induced cortical remodeling to investigate mechanism and treatment, based on robust preliminary work in the laboratories of the three multiPIs. The study will test the central hypothesis that BPs degrade skeletal integrity by affecting both the initiation of bone formation and matrix maturation. We will focus on alendronate because of its strong association with the development of AFFs and raloxifene as a potential mitigating treatment due to its reported positive effects on both the formation and matrix maturation processes. As an associated side project, we will also investigate the effect of long-term alendronate treatment in osteoporotic patients in bone biopsies collected from an ongoing clinical study ALEXIS.
Tasks
The postdoc will - as part of the research team focusing on the proposed project - be responsible for:
The position as postdoc at the MBH lab will give you the opportunity to become a leading-edge expert in histomorphometry, and molecular and spatial imaging, being at the frontline of the rapid developing field.
Expectation of qualifications
The candidate must hold a Ph.D.-degree and documented research experience in one or more of the following areas/fields/methodologies:
Contact
For further information please contact the head of the MBH lab, associate professor Thomas Levin Andersen, phone: +45 222284772/e-mail [email protected], the Head of Research, Pathology Research Unit, Kent Søe, phone: +45 21364883/ e-mail: [email protected] or the Head of the Department of Clinical Research Kirsten Ohm Kyvik, phone: 6011 3046/ e-mail: [email protected]
Conditions of employment
The Recruitment/Hiring takes place in accordance with the agreement between the Ministry of Finance and the Central Organization of the Academics.
Application
Assessment of applicants will be done in accordance with the current/applicable university recruitment order. Applicants will be assessed by an expert committee, and applicant will be informed of their assessment by the university.
Applications may be shortlisted.
Applications - including the required attachments - must be sent electronically via the below-mentioned link "Apply online". Only online applications will be accepted and assessed. Attached files must be Adobe PDF or Word format. Each field in the application form can contain up to max. 10 MB.
Only applications written in English will be accepted for evaluation.
The application must include (as PDF- or docx-files):
Incomplete applications will not be assessed.
See also the faculty's guidance for applicants at the link below.
Living and Working in Denmark
Foreign applicants will be offered Danish language training as part of the employment. The International Staff Office (ISO) at SDU provides a variety of services for new employees, guests and people who consider applying for a job at the University of Southern Denmark.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Further Details
Guide for applicants
The 4-year position is open from January 1, 2024, or as soon as possible thereafter and will be agreed with the successful candidate.
The MBH labis headed by Associate Professor Thomas Levin Andersen with the overarching aim of facilitating a better understanding of bone and bone diseases, including osteoporosis and its treatment.
The MBH lab within the Research Unit of Pathology hosts the Danish Spatial Imaging Consortium (DanSIC) utilizing the newest technologies within molecular spatial histology, allowing detailed transcriptomic analysis while maintaining the spatial context. The MBH lab is part of a hot spot in Danish bone research with six neighboring teams including +40 scientists, technicians and students all focusing on different aspects of bone research.
The open postdoc position is funded by a multi-PI NIH R01 grant (1R01AR080118-01A1) in collaboration with Dr. Ryan Ross from the Rush University Medical Center, Chicago, US, and Dr. Joseph Wallace, Indiana University, Indianapolis, US. The project is entitled: "How bisphosphonates affect bone matrix and remodeling: implications for atypical femoral fractures".
Atypical femoral fractures (AFFs) are a rare but devastating side effect of long-term bisphosphonate (BP) treatment. Despite the relatively low prevalence of AFFs, public awareness has considerably depressed osteoporosis medication adherence. The mechanisms driving BP associated AFFs remain elusive and several mechanisms have been proposed, including impaired bone remodeling, altered bone matrix maturation, and the accumulation of tissue microdamage. A critical barrier to understanding how BPs negatively affect skeletal integrity is the difficulty in separating the individual contributions of altered remodeling kinetics (suppressed resorption and formation) from bone matrix maturation. We will overcome this barrier with our recently validated rat model of induced cortical remodeling to investigate mechanism and treatment, based on robust preliminary work in the laboratories of the three multiPIs. The study will test the central hypothesis that BPs degrade skeletal integrity by affecting both the initiation of bone formation and matrix maturation. We will focus on alendronate because of its strong association with the development of AFFs and raloxifene as a potential mitigating treatment due to its reported positive effects on both the formation and matrix maturation processes. As an associated side project, we will also investigate the effect of long-term alendronate treatment in osteoporotic patients in bone biopsies collected from an ongoing clinical study ALEXIS.
Tasks
The postdoc will - as part of the research team focusing on the proposed project - be responsible for:
- The molecular histology and histomorphometry of the bone remodeling in bones from the rat model of AFF development.
- Contribution to the animals studies while visiting Dr. Ross lab in Chicago.
- Facilitating the handling and investigation of patient bone biopsies obtained from the clinical study ALEXIS.
- Histomorphometry and advanced bone histology on the human bone biopsies using computer-assisted analysis. The advanced bone histology may likely utilize our new methodologies within spatial-resolved transcriptomic.
- Applying for additional funding for the project.
- Supervising students involved in the project.
- Taking part in the future development of the collaboration with Dr. Ross and other involved partners.
The position as postdoc at the MBH lab will give you the opportunity to become a leading-edge expert in histomorphometry, and molecular and spatial imaging, being at the frontline of the rapid developing field.
Expectation of qualifications
The candidate must hold a Ph.D.-degree and documented research experience in one or more of the following areas/fields/methodologies:
- Histology and computer-assisted image analysis
- In situ hybridization and immunostaining
- Transcriptomics in a spatial context
- Molecular biology
- Bioinformatics on RNAseq data
- Bone research
- Teaching and supervision of bachelor, master and PhD students
- Management of research projects
Contact
For further information please contact the head of the MBH lab, associate professor Thomas Levin Andersen, phone: +45 222284772/e-mail [email protected], the Head of Research, Pathology Research Unit, Kent Søe, phone: +45 21364883/ e-mail: [email protected] or the Head of the Department of Clinical Research Kirsten Ohm Kyvik, phone: 6011 3046/ e-mail: [email protected]
Conditions of employment
The Recruitment/Hiring takes place in accordance with the agreement between the Ministry of Finance and the Central Organization of the Academics.
Application
Assessment of applicants will be done in accordance with the current/applicable university recruitment order. Applicants will be assessed by an expert committee, and applicant will be informed of their assessment by the university.
Applications may be shortlisted.
Applications - including the required attachments - must be sent electronically via the below-mentioned link "Apply online". Only online applications will be accepted and assessed. Attached files must be Adobe PDF or Word format. Each field in the application form can contain up to max. 10 MB.
Only applications written in English will be accepted for evaluation.
The application must include (as PDF- or docx-files):
- A Cover letter
- A CV
- Copies of certificates/diplomas including evidence of acquisition of a PhD degree or equivalent
- A complete and numbered list of publications
- The 3 scientific, peer-reviewed publications that the applicant wishes to be included in the assessment of his or her scientific qualifications. (Please note that one PDF or docx file must be attached for each publication).
- A research plan
- A teaching portfolio
- An explanation of other qualifications relevant to the position.
Incomplete applications will not be assessed.
See also the faculty's guidance for applicants at the link below.
Living and Working in Denmark
Foreign applicants will be offered Danish language training as part of the employment. The International Staff Office (ISO) at SDU provides a variety of services for new employees, guests and people who consider applying for a job at the University of Southern Denmark.
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
Further Details
Guide for applicants
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Odense M.
Jobbet er oprettet på vores service den 11.9.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Odense M
- Søndag den 08. oktober 2023
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