Scientist for Protein Purification and Biophysical Characterization

Dragonfly TX is seeking a highly motivated and talented protein biochemist to join our Biologics team in Copenhagen as protein purification scientist.

The successful candidate will be a key player in purification of high quality antibody reagents, state-of-the-art protein characterization and advancement of downstream processes, to support progression of Dragonfly’s projects and platform innovation. The successful candidate will work together with Dragonfly’s dedicated global Biologics and Biology teams, to discover and develop therapies that modulate immune responses in cancers and autoimmune diseases. Dragonfly TX is an exciting young company that offers a fantastic culture and great opportunities to enhance your skills and grow your career!

Core Responsibilities

• Purification of mono- and multi-specific antibody reagents and therapeutic candidates.
• Purification of protein reagents to support new antibody discovery campaigns.
• Anchor reagent/antibody quality assessment through comprehensive characterization by SDS-PAGE, CE, SEC-HPLC, cIEF, DSF etc.
• Drive high-throughput purification process innovation to enable early functional screening in antibody discovery campaigns.
• Contribute to antibody candidate selection through biophysical qualification of antibody candidates, using predictive biophysical developability assays.
• Support bioinformatics-based mining of in-house and external structure-function/ biophysical data for early in-silico qualification and ranking of antibody candidates.
• Active participation in projects, including coordination of protein reagent generation/screening and candidate selection activities.
• Maintain electronic laboratory notebooks and records to support technology transfer to internal or external groups as well as to support regulatory filings.

Qualifications

• PhD. with a quality mindset and industrial experience in protein purification, characterization and biophysical qualification.
• Extensive hands-on experience with downstream processing of mono- and bispecific antibodies, Fab fragments, scFv/dAb domains and various antibody-fusion formats.
• Proven experience with purification of proteins using affinity, IEX, HIC and other chromatography methods.
• Hands-on experience with ÄKTA Chromatography systems, including the ability to develop custom methods and process troubleshooting.
• Experience with basic and advanced protein characterization techniques, including methods for antibody developability assessment.
• Team player with an innovative attitude and the ability to multi-task in a fast-paced environment with changing priorities.
• Excellent record keeping abilities, to document analytical data generated in support of regulatory requirements, adherence to GDP, experience with ELN.

About Dragonfly
Founded in 2015 by Dr. Tyler Jacks, head of the Koch Institute at MIT, Dr. David Raulet, one of the world's leading experts in Natural Killer (NK) cell biology, and Bill Haney, a longtime tech entrepreneur and investor, Dragonfly Therapeutics was launched to harness the power of the immune system to provide breakthrough treatments for patients – especially in areas where there are no effective treatments, today.

The company develops novel first-in-class therapeutics designed to harness Natural Killer cells and other cells of the innate immune system which can provide direct killing of disease promoting cell types, and provide a unique therapeutic window beyond current therapies for treatment of cancer and chronic inflammatory diseases. Please visit our website for details.

We offer
Our employees are fundamental to our success, and we continue to be able to attract and retain people with different experiences and backgrounds. We have a high-performing, collaborative culture characterized by respectful and diverse teams who are committed to our patients first mission.

At Dragonfly, you will have the opportunity to have impact, work with some of the brightest minds in the industry, develop your professional career, and contribute to breakthrough medicines for patients with urgent unmet medical needs.

Your application
Please apply by sending a cover letter and resume as soon as possible through the button "Apply / Send ansøgning". We are screening and interviewing for the position on an ongoing basis. For any further questions please contact Berit Olsen Krogh on email ([email protected]).

For more info, check out our career site https://dragonflytx.ofir.com

Denne jobannonce blev oprindeligt opslået på https://www.ofir.dk/
(Den originale annonce kan ses på: https://www.ofir.dk/showojob?ofirid=03feaecc)
Kilde: Jobnet.dk