Experienced Biomarker Assay Specialist
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Ballerup
If you have extensive experience within biomarker discovery and quantitative biomarker analyses and you are looking for a unique opportunity to help bridge early drug discovery and clinical trials, this may just be the job for you.
LEO Pharma has set the ambitious goal to be pioneering in dermatology and become the world’s preferred dermatology care partner. You can play a significant role in making this vision come through. You will join a successful, global company and contribute to our common goal of improving the lives for people around the world who live with a medical skin condition.
You have a strong and proven track record within development and validation of biomarker assays as translatable measures of target engagement, pharmacodynamic response and disease progression. You have a deep understanding of the bioanalysis requirements needed to support PKPD understanding and clinical dose-setting. You can drive biomarker identification initiatives and propose relevant project biomarker strategies incorporating your broad knowledge within immunology. You thrive with establishing and optimizing biomarker assays and you are proficient in identifying and executing on strategies to measure free, drug bound, and total analytes.
The Translational Science & Biomarker Team consists of 9 highly skilled, dedicated and experienced Technicians and Scientists within bioanalysis, histology and immunology. We are responsible for identification, development and execution of biomarker assays for preclinical in vivo pharmacology studies and first-in-man clinical trials. Additionally, we support the entire drug development chain with histology analyses. Our team is characterized by an open informal working atmosphere and a collaborative and knowledge sharing mind-set.
As a biomarker assay specialist, you can look forward to help shape and further advance our translational platform in an environment based on trust and empowerment – your ideas are highly valued, and you can expect full support to ensure your on-going development.
Does this sound like you and do you want to take part in creating new therapies that really make a difference in patients' lives?
For further information, please contact Manager Malene Bertelsen (+45 4188 9517).
Applications will be evaluated on a continuous basis until 27th January 2021.
LEO Pharma has set the ambitious goal to be pioneering in dermatology and become the world’s preferred dermatology care partner. You can play a significant role in making this vision come through. You will join a successful, global company and contribute to our common goal of improving the lives for people around the world who live with a medical skin condition.
About you
You have a strong and proven track record within development and validation of biomarker assays as translatable measures of target engagement, pharmacodynamic response and disease progression. You have a deep understanding of the bioanalysis requirements needed to support PKPD understanding and clinical dose-setting. You can drive biomarker identification initiatives and propose relevant project biomarker strategies incorporating your broad knowledge within immunology. You thrive with establishing and optimizing biomarker assays and you are proficient in identifying and executing on strategies to measure free, drug bound, and total analytes.
About us
The Translational Science & Biomarker Team consists of 9 highly skilled, dedicated and experienced Technicians and Scientists within bioanalysis, histology and immunology. We are responsible for identification, development and execution of biomarker assays for preclinical in vivo pharmacology studies and first-in-man clinical trials. Additionally, we support the entire drug development chain with histology analyses. Our team is characterized by an open informal working atmosphere and a collaborative and knowledge sharing mind-set.
As a biomarker assay specialist, you can look forward to help shape and further advance our translational platform in an environment based on trust and empowerment – your ideas are highly valued, and you can expect full support to ensure your on-going development.
Your role will be to:
- Leverage understanding of target specific biology to identify biomarker assays of direct and indirect target occupancy, target function modulation and pathway suppression.
- Explore and select biomarker assay formats, evaluate candidate biomarkers in relevant biological matrices relevant to skin diseases (e.g. skin, blood) and establish robust biomarker assays to support pre-clinical in vivo models and early clinical trials.
- Act as subject-matter expert within quantitative assessment of free, drug bound, total analytes (e.g drug and/or target) and target occupancy under dynamic conditions.
- Ensure timely execution and quality control of biomarker assays supporting in vivo pharmacology studies in close collaboration with assay technicians
- Provide strategic input and technical guidance to project biomarker strategies and closely collaborate with key stakeholders within Skin Biology, DMPK and Medical Sciences.
- Identify and stay updated on trends and state-of-the-art technologies within biomarker assays introducing relevant novel opportunities to the team.
- Help promote a culture of curiosity and entrepreneurship while maintaining accountability, high-performance science delivery, data driven decisions and timely progression of own tasks.
We expect as a minimum:
- +5 years in a pharmaceutical company research environment and a PhD in biochemistry, biology, biomedicine or related field
- Deep understanding and demonstrated proficiency in assay optimization and validation across different immunoassay formats (e.g. MSD, ELISA)
- Solid experience with biomarker assay development using multiple analytical methodologies (e.g. RNA analysis, flow cytometry)
- Extensive experience in immunology and diseases driven by inflammatory processes.
- Broad knowledge of discovery, development and utilization of biomarkers and their associated technologies in a research or clinical setting.
- A strong team player, who easily builds and maintains both internal and external relationships to create synergy and foster collaboration.
- Excellent communication skills and proficiency in written and spoken English.
- It will be considered an advantage if you have worked with both biologics and small molecule drugs
Does this sound like you and do you want to take part in creating new therapies that really make a difference in patients' lives?
For further information, please contact Manager Malene Bertelsen (+45 4188 9517).
Applications will be evaluated on a continuous basis until 27th January 2021.
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i Ballerup.
Jobbet er oprettet på vores service den 22.12.2020, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- Ballerup
- Onsdag den 27. januar 2021
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