Sr. Scientist/Specialist - Computational Peptide Design
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Are you a highly skilled computational scientist with a passion for peptide drug design? Are you ready to take on the challenge of designing ultra large peptide libraries and developing complex workflows to support the selection, design, and optimization of peptide modalities? We are looking for a Sr. Scientist/Specialist - Computational Peptide Design to join our team at Novo Nordisk and contribute to our efforts towards exploring and creating new technology in peptide drug design. If you thrive in a fast-paced and collaborative environment, read on and apply today for a life-changing career. The Position The Sr. Scientist/Specialist – Computational Peptide Design will be an important team member of Molecular AI and contribute to the research team's effort towards exploring and creating new technology and continuing to be a world expert in peptide drug design. In this position, you will work closely with Research Chemistry to develop new technologies and design ultra large peptide libraries. Additionally, you will be responsible for developing complex workflows to support the selection, design and optimization of peptide modalities. In this exciting position, among others, your broad range of responsibilities will include: Contributing to on-going portfolio projects within multiple therapy areas. Designing and optimizing drug candidates using advanced computational techniques. Developing innovative computational methods for peptide modeling and ultra large peptide libraries. Analyzing and drawing conclusions from large datasets. Maintaining a well-documented, reusable codebase, and traceable model history Working closely with Therapeutic areas, Research Chemistry and Biophysics and Formulations teams to drive discovery and development efforts Actively participating in cross-functional teams to develop AI and ML models and solutions. The Sr. Scientist/Specialist – Computational Peptide Design reports to the Head of Molecular AI. They will have close interactions with scientists and experts within Research Chemistry. Additional internal partners include data scientists, specialists, engineers, software developers, technology scouts & partnership developers and others across US and Denmark. External relationships include commercial and academic collaboration partners. For this position you will be based in Maaloev (Copenhagen area, Denmark) or London (UK). Please note that it is also possible to work from Boston, if that is your wish, you will need to submit your application via this link. Qualifications To succeed in this position, we imagine you have: Master’s Degree with 3+ years’ relevant experience or PhD with 1+ years’ of relevant experience with peptide structure-based design methods using conformational analysis, amino acid monomers, in silico mutation, property prediction or similar. Experience related to ultra large library design and macrocyclic design would be a plus. Proficiency in Python (or other scientific programming) to curate and analyze data at scale and to implement new metrics to predict and select peptide designs. It would be advantageous if you have experience with QSAR, machine learning, deep learning. Proficiency with at least one modeling software package (e.g. Schrodinger, Rosetta, similar). Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, ligand- and structure-based design). As a person, you have excellent written and oral communication skills and are good at engaging stakeholders in a cross-functional, multi-disciplinary setting. As a science-driven detail-oriented person, you have the ability to perform in-depth data analysis and present results and conclusions to engineering and leadership teams. Furthermore, you will show initiative in recognizing and addressing unmet scientific needs using internal and external data and the desire to grow outside their comfort zone. About the Department The Molecular AI team is part of Novo Nordisk’s Computational Drug Design (CDD) area where we apply and develop state of the art capabilities in predictive science, AI/ML and structure-based drug design. Scientists within CDD collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased approach to drug modalities, in-house access to the newest screening techniques, and world-class experimentation, we have a wealth of opportunities to impact our pipeline and ultimately save and improve patient lives. We work in multidisciplinary, highly collaborative discovery teams both locally and across Novo Nordisk’s global network to invent novel medicines by applying advanced computational techniques and developing innovative computational methods. We engage in external collaborations to ensure access to cutting edge research and technology. Molecular AI is working to establish ourselves as global leaders in the research, development, and application of small molecules, peptides and RNA. We support cutting-edge research projects and develop innovative technologies in this field. We foster strong collaborations with Research Chemistry within our Global Research and Technology (GRT) organization and the Global Nucleic Acid Therapies (GNAT). With a team of scientists located in both Denmark and the United States, we strive to deliver the latest advancements in small molecules, peptides and RNA to benefit patient health and global medicine. Working at Novo Nordisk At Novo Nordisk, we use our skills, dedication, and ambition to help people with diabetes and other cardiometabolic diseases. We offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development. We are a proud life-science company, and life is our reason to exist. We’re inspired by life in all its forms and shapes, ups and downs, opportunities, and challenges. For employees at Novo Nordisk, life means many things – from the building blocks of life that form the basis of ground-breaking scientific research to our rich personal lives that motivate and energize us to perform our best at work. Ultimately, life is why we’re all here - to ensure that people can lead a life independent of chronic disease. Deadline 15 August 2024. Applications will be reviewed on an ongoing basis, so we encourage you to apply as soon as possible. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo to your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
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Denne ledige stilling har jobtypen "Softwareudvikler", og befinder sig i kategorien "Informationsteknologi".
Arbejdsstedet er beliggende i Måløv.
Jobbet er oprettet på vores service den 2.8.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
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