Principal Scientist (in vitro biological assays)

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Do you have a strong background within receptor pharmacology and development of in vitro biological assays for drug candidate screening purposes? And do you want to apply your skills and knowledge in an international, ambitious, and collaborative team? If yes, then you could be our new colleague in the Centre for Functional Assays & Screening. The position We are expanding both within our core and new therapeutic areas and therefore efficient predictive in vitro screening tools are needed to facilitate medium and high throughput screening of peptides, proteins as well as other drug modalities. In the role as a Principal Scientist, your main responsibilities include:
  • Designing, developing, and conducting advanced and robust cellular in vitro assays to aid the selection of drug candidates.
  • Being a key driver of the design and execution of medium- or high-throughput screening assays, primarily supporting our T2D and obesity portfolio.
  • Contributing to maturing and advancing scientific ideas into projects including development and improvement of screening strategies to select the best drug candidates within different therapeutic areas.
    • In your daily work, you will collaborate closely with project teams, department scientists, and laboratory technicians. Our research and discovery work is organized in multidisciplinary cross-functional project teams, and you will represent the department across a range of projects. The working environment in Global Research Technologies is dynamic and innovative and involves interactions with colleagues from research sites in Denmark, US, UK, and China, with an excellent opportunity to establish a strong global scientific network. Qualifications To thrive and succeed in the role, we expect you to have:
  • PhD in cell biology, immunology, biochemistry, or a related discipline and at least 7 years of post-degree experience from the pharmaceutical industry with preclinical development of drug candidates (preferably peptides and proteins)
  • Extensive receptor pharmacology knowledge, preferably GPCR expert knowledge.
  • Solid experience in design, development, and execution of cellular in vitro functional assays based on the use of engineered cell lines. Assays of relevance comprise, but are not limited to molecular pharmacology assays detecting signal transduction e.g. reporter gene assays, receptor binding assays, high-content imaging, and FRET assays.
  • Experience with liquid handlers (e.g., Biomek, Hamilton or Tecan) and automated/semi-automated workflows for efficient screening processes.
    • It is an advantage to have a solid track record of engagement with cross-disciplinary scientists to evaluate targets for new drug discovery projects. Strong analytical and statistical skills and a flair for programming (R or Python) are likewise a plus. As a person, you are curious and open-minded to new ideas, people, and challenges. You have excellent communication skills, and you are good at establishing and maintaining connections externally and internally. You thrive in a changing and dynamic work environment, and you enjoy working in teams to share knowledge. Your passion for science and ability to impact and progress projects inspires those around you. About the Department The Centre for Functional Assays & Screening is part of Global Research Technologies at Novo Nordisk located in Maaloev in the Copenhagen area of Denmark. We specialise in the design and execution of a variety of medium- and high-throughput screening assays with relevant biological read-outs and with a strong focus on automation and digitalisation. We deliver high-quality in vitro data to support the identification of drug candidates with desired functionalities in close collaboration with other parts of the research organization. CFAS consists of three sub-departments and comprises a total of 15 scientists, three associate scientists, 13 technicians as well as two students. You will be part of a high-performing, multidisciplinary team exploring and identifying new treatment options for diabetes, obesity, NASH, cardiovascular and kidney disease, haemophilia, and other rare blood and endocrine disorders. Working at Novo Nordisk At Novo Nordisk, we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing and sales – we’re all working to move the needle on patient care. Contact For further information, please contact Director Tine Glendorf at (+45) 30 75 62 77. Deadline 11 June 2023. Applications will be reviewed on an ongoing basis, so we encourage you to apply as soon as possible. You do not need to attach a cover letter to your application, but please include a few sentences about why you are applying in your resume or CV. To ensure an efficient and fair recruitment process, please refrain from adding a photo to your CV. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.


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    Denne ledige stilling har jobtypen "Forretningsudvikler", og befinder sig i kategorien "Kommunikation, marketing, salg".

    Arbejdsstedet er beliggende i Måløv.

    Jobbet er oprettet på vores service den 23.5.2023, men kan have været deaktiveret og genaktiveret igen.

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