PhD fellowship available on a research project investigating effects of vitamin K supplementation on cardio-metabolic...
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Frederiksberg
A three-year PhD position is open at the Center for Clinical Research and Prevention (CCRP), Section of Epidemiology, Bispebjerg and Frederiksberg Hospital, The Capital Region.
About the project
The Danish researcher Henrik Dam was awarded the Nobel Prize for his discovery of vitamin K as an essential vitamin for the activation of blood clotting factors. Beyond this, there is growing evidence that vitamin K is important for activation of other proteins important to human physiology and the prevention of age-related diseases. The overall objective of the project is to investigate health effects of vitamin K beyond coagulation. The project is based on the 20-year follow-up of the Inter99 study including a comprehensive health examination and cardiometabolic profiling (clinicaltrial.gov identifier: NCT05166447). Eligible participants will be invited to participate in the InterVitaminK trial (clinical trials.gov identifier: NCT05259046).
The InterVitaminK trial investigates the effect of daily vitamin K supplementation on cardio-metabolic and bone health in a randomized double-blinded placebo-controlled intervention trial. The aim is to provide proof-of-concept evidence that vitamin K has a potential for prevention of age-related diseases. 450 men and women will be randomized to receive one daily tablet of vitamin K or placebo for 3 years. Health examinations are scheduled at baseline, and after 1-, 2- and 3 years of intervention. The primary outcome is progression of coronary artery calcification assessed by cardiac computed tomography (CT)-scan. Secondary outcomes include arterial stiffness, blood pressure, bone mineral density, lung function, lung tissue density, and various biomarkers e.g., of glucose and bone metabolism.
About the position
The three-year PhD position is fully funded by a research grant from The Independent Research Fund Denmark. The PhD student will receive training in epidemiological and clinical research methods and radiology imaging techniques.
The PhD fellow will be part of an interdisciplinary and ambitious project team with expertise within medical imaging techniques, cardiology, epidemiology, nutrition, and clinical research. The team has a special interest in effects of micronutrients such as vitamins and minerals on various chronic diseases, e.g., cardiovascular, endocrinological, and respiratory diseases. The candidate will be enrolled as PhD-student at the University of Copenhagen. The PhD-supervisor team consists of Klaus Fuglsang Kofoed, Freja Bach Kampmann, Line Lund Kårhus, and Allan Linneberg (Faculty supervisor). The project is a collaboration between several institutions, primarily CCRP, Rigshospitalet, and Steno Diabetes Center Copenhagen. The candidate must expect 2–3 working days/week at CCRP and 2–3 working days/week at Dept. of Cardiology, Rigshospitalet, where the cardiac CT-scans will be performed and interpretated supervised by experienced members of the team. Health examinations in the Inter99 study and the InterVitaminK trial take place at Glostrup Hospital.
Responsibilities and tasks
Qualifications
We are looking for applicants with a Medical Degree and an interest in cardiology or radiology with the following qualifications:
About The Center for Clinical Research and Prevention (CCRP)
The candidate will be employed at the CCRP. The CCRP is an ambitious and internationally recognized research center with expertise in population-based epidemiology, clinical epidemiology, pharmaco-epidemiology, health promotion and prevention, and biostatistics. Our overall goal is to contribute to a healthier population through improving disease prevention and treatment and by promoting physical mental and social wellbeing. Our research is characterized by a multidisciplinary approach to health research covering basic research into the causes of diseases, research into patient care and disease treatment, and research into effective health promotion and preventive interventions focused on increasing public health. The CCRP is organizationally located as a department at Bispebjerg and Frederiksberg Hospital. The CCRP is currently located at Frederiksberg Hospital but has also a data collection facility at Glostrup Hospital. More information about CCRP can be found at: https://www.frederiksberghospital.dk/ckff/sider/CKFF.aspx
Terms of employment
The position is full time and limited to 3 years. Salary and employment conditions are in accordance with the regional collective agreements. The starting date is February 1, 2023 (or the earliest available date, by mutual agreement).
Application
Your application must include the following:
Please submit the application with the required attachments. Only online applications will be accepted. Application deadline is Tuesday, January 10, 2023, at 23:59.
First round of interviews is expected to be held Wednesday, January 18, 2023.
Further Information:
If you have any questions about the position, please contact professor, director Allan Linneberg, Phone: + 45 40546992 or mail: [email protected]
Kilde: Jobnet.dk
About the project
The Danish researcher Henrik Dam was awarded the Nobel Prize for his discovery of vitamin K as an essential vitamin for the activation of blood clotting factors. Beyond this, there is growing evidence that vitamin K is important for activation of other proteins important to human physiology and the prevention of age-related diseases. The overall objective of the project is to investigate health effects of vitamin K beyond coagulation. The project is based on the 20-year follow-up of the Inter99 study including a comprehensive health examination and cardiometabolic profiling (clinicaltrial.gov identifier: NCT05166447). Eligible participants will be invited to participate in the InterVitaminK trial (clinical trials.gov identifier: NCT05259046).
The InterVitaminK trial investigates the effect of daily vitamin K supplementation on cardio-metabolic and bone health in a randomized double-blinded placebo-controlled intervention trial. The aim is to provide proof-of-concept evidence that vitamin K has a potential for prevention of age-related diseases. 450 men and women will be randomized to receive one daily tablet of vitamin K or placebo for 3 years. Health examinations are scheduled at baseline, and after 1-, 2- and 3 years of intervention. The primary outcome is progression of coronary artery calcification assessed by cardiac computed tomography (CT)-scan. Secondary outcomes include arterial stiffness, blood pressure, bone mineral density, lung function, lung tissue density, and various biomarkers e.g., of glucose and bone metabolism.
About the position
The three-year PhD position is fully funded by a research grant from The Independent Research Fund Denmark. The PhD student will receive training in epidemiological and clinical research methods and radiology imaging techniques.
The PhD fellow will be part of an interdisciplinary and ambitious project team with expertise within medical imaging techniques, cardiology, epidemiology, nutrition, and clinical research. The team has a special interest in effects of micronutrients such as vitamins and minerals on various chronic diseases, e.g., cardiovascular, endocrinological, and respiratory diseases. The candidate will be enrolled as PhD-student at the University of Copenhagen. The PhD-supervisor team consists of Klaus Fuglsang Kofoed, Freja Bach Kampmann, Line Lund Kårhus, and Allan Linneberg (Faculty supervisor). The project is a collaboration between several institutions, primarily CCRP, Rigshospitalet, and Steno Diabetes Center Copenhagen. The candidate must expect 2–3 working days/week at CCRP and 2–3 working days/week at Dept. of Cardiology, Rigshospitalet, where the cardiac CT-scans will be performed and interpretated supervised by experienced members of the team. Health examinations in the Inter99 study and the InterVitaminK trial take place at Glostrup Hospital.
Responsibilities and tasks
- Carry out scientific tasks related to the project, including statistical and epidemiological analyses, writing of scientific articles and other communication of results, in collaboration with the supervisors and other members of the project team
- Responsible for coordinating CT-scans including annotation and interpretation of CT-scan data.
- Contribute to health examinations, recruitment of participants, and communication with participants
Qualifications
We are looking for applicants with a Medical Degree and an interest in cardiology or radiology with the following qualifications:
- Interest in learning cardiac imaging techniques
- Ability to work both independently and as part of a team
- Good communication skills in Danish and English, both written and orally
- Research experience including experience in writing and publishing scientific papers is an advantage
- Experience with statistics and programming in SAS or similar software is an advantage
About The Center for Clinical Research and Prevention (CCRP)
The candidate will be employed at the CCRP. The CCRP is an ambitious and internationally recognized research center with expertise in population-based epidemiology, clinical epidemiology, pharmaco-epidemiology, health promotion and prevention, and biostatistics. Our overall goal is to contribute to a healthier population through improving disease prevention and treatment and by promoting physical mental and social wellbeing. Our research is characterized by a multidisciplinary approach to health research covering basic research into the causes of diseases, research into patient care and disease treatment, and research into effective health promotion and preventive interventions focused on increasing public health. The CCRP is organizationally located as a department at Bispebjerg and Frederiksberg Hospital. The CCRP is currently located at Frederiksberg Hospital but has also a data collection facility at Glostrup Hospital. More information about CCRP can be found at: https://www.frederiksberghospital.dk/ckff/sider/CKFF.aspx
Terms of employment
The position is full time and limited to 3 years. Salary and employment conditions are in accordance with the regional collective agreements. The starting date is February 1, 2023 (or the earliest available date, by mutual agreement).
Application
Your application must include the following:
- A letter motivating the application (cover letter)
- Curriculum Vitae including references/recommendations and list of publications (if any)
- Diploma including grades
Please submit the application with the required attachments. Only online applications will be accepted. Application deadline is Tuesday, January 10, 2023, at 23:59.
First round of interviews is expected to be held Wednesday, January 18, 2023.
Further Information:
If you have any questions about the position, please contact professor, director Allan Linneberg, Phone: + 45 40546992 or mail: [email protected]
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Frederiksberg.
Jobbet er oprettet på vores service den 5.12.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Frederiksberg
- Tirsdag den 10. januar 2023
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