PhD scholarship in Discovery of new fungal enzymes for degradation of thermoset plastics - DTU Bioengineering
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Kongens Lyngby
This position is offered in connection to the project Center for enzymatic deconstruction of thermoset plastics for a sustainable society (En’Zync). The center has just started and will operate for at least six years and is financed by support of the Novo Nordisk Foundation. The center will offer excellent opportunities for further development of your carrier within biotechnology in general and enzyme technology in particular,and it houses leading expertise in the range of disciplines that are required for the discovery and -engineering industrial biocatalysts. Main center activities are within molecular biology, enzymology, structural biology, organic synthesis and computational biochemistry.
Responsibilities and qualifications
Your focus will be to identify new enzymes for degradation of thermoset plastics. You will follow two strategies. One will use bioinformatics approaches to identify potential gene candidates. Gene candidates will be inserted into fungal expression platforms based on e.g. Aspergillus niger and Aspergillus oryzae , using high-throughput methods. The resulting enzyme cell factories will be tested for novel activities in relevant assays. The other will screen a large collection systematically for relevant activities. Plastic degrading enzymes will be isolated and genes identified. Next, efficient cell factories will be constructed for enzyme production. The enzymes will be characterized by biochemists within the center and by collaborators. In this process, you will work with nearby colleagues in the center at DTU, in Aarhus and abroad.
Your primary tasks will be to:
Important qualifications are therefore:
You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education .
Assessment
The assessment of the applicants will be made by Uffe Mortensen, Peter Westh, and Jens Preben Morth
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths.
Further information
Further information may be obtained from Uffe Mortensen (https://www.bioengineering.dtu.dk/english/ResearchNy/Research-Sections/Section-for-Synthetic-Biology/Eukaryotic-molecular-cell-Biology )
You can read more about The Department of Biotechnology and Biomedicine at https://www.bioengineering.dtu.dk/english.
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.
Application procedure
Your complete online application must be submitted no later than 20 December 2022 (Danish time).
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now”, fill out the online application form, and attach all your materials in English in one PDF file . The file must include:
You may apply prior to obtaining your master's degree but cannot begin before having received it.
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,400 students and 5,800 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
Kilde: Jobnet.dk
Responsibilities and qualifications
Your focus will be to identify new enzymes for degradation of thermoset plastics. You will follow two strategies. One will use bioinformatics approaches to identify potential gene candidates. Gene candidates will be inserted into fungal expression platforms based on e.g. Aspergillus niger and Aspergillus oryzae , using high-throughput methods. The resulting enzyme cell factories will be tested for novel activities in relevant assays. The other will screen a large collection systematically for relevant activities. Plastic degrading enzymes will be isolated and genes identified. Next, efficient cell factories will be constructed for enzyme production. The enzymes will be characterized by biochemists within the center and by collaborators. In this process, you will work with nearby colleagues in the center at DTU, in Aarhus and abroad.
Your primary tasks will be to:
- Carry out bioinformatics analyses
- Construct fungal strains in a high-throughput cloning platform
- Implement screening procedures of enzyme discovery
- Produce novel enzymes
- Teach and supervise BSc and MSc student projects
Important qualifications are therefore:
- Documented use of basic bioinformatics
- Experience with genetic engineering in fungi
- Experience with enzyme production
You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education .
Assessment
The assessment of the applicants will be made by Uffe Mortensen, Peter Westh, and Jens Preben Morth
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths.
Further information
Further information may be obtained from Uffe Mortensen (https://www.bioengineering.dtu.dk/english/ResearchNy/Research-Sections/Section-for-Synthetic-Biology/Eukaryotic-molecular-cell-Biology )
You can read more about The Department of Biotechnology and Biomedicine at https://www.bioengineering.dtu.dk/english.
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.
Application procedure
Your complete online application must be submitted no later than 20 December 2022 (Danish time).
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now”, fill out the online application form, and attach all your materials in English in one PDF file . The file must include:
- A letter motivating the application (cover letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale
You may apply prior to obtaining your master's degree but cannot begin before having received it.
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,400 students and 5,800 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Kongens Lyngby.
Jobbet er oprettet på vores service den 8.12.2022, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Kongens Lyngby
- Tirsdag den 20. december 2022
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