Scientist for stem cell process development and analysis

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Do you want to play a significant role in the process development for stem cell GMP manufacturing and do you have experience with pluripotent stem cells, genome editing and molecular assays? Then this job will be just right for you.

About the department

The department Stem Cell Process Development is part of Novo Nordisk’s newly established Stem Cell R&D unit, where we develop novel cell replacement therapies for the treatment of serious chronic diseases. Our department focuses on the development of stem cell manufacturing processes and related analyses. We control processes across the entire pluripotent stem cell workflow, starting with cell line derivation and ending with an efficacious and well-characterised product. Diabetes mellitus type 1, Parkinson’s disease and chronic heart failure are only some of the indications we are currently working on. You will join an international and dedicated group of around 35 employees, including scientists, project leaders, laboratory technicians and student workers. We have expertise in bioprocess development, stem cell biology and GMP compliance and truly believe that stem cell therapies will make a difference in the lives of patients suffering from chronic diseases. If this awakens your interest, please apply and support us in progressing our stem cell projects into the clinic

The position

As a scientist in Stem Cell Process Development your key responsibilities will be in developing manufacturing processes and analytical methods for human pluripotent stem cell-based products and gene edited derivatives. The successful candidate independently plans and executes process and -molecular assay development, characterisation studies as well as performs data collection, -analysis and -interpretation. The position will also cover designing experiments and coordination with laboratory technicians and associates, as well as the responsibility for ensuring a successful technical transfer of the processes to relevant manufacturing sites. The latter includes preparation of study reports, technical transfer documentation and hands-on/classroom training of the receiving facility.

As a major part of the job responsibility includes hands on processes and assay development, the preferred candidate is a highly motivated researcher with desire to work in a laboratory-focused role.

You will work in close collaboration across the organisation with skilled colleagues from research, manufacturing, analytics, virology, raw materials, QA and RA to ensure progress and alignment in our projects according to timelines.

Qualifications

You must hold a scientific academic degree in life sciences (human biology, biochemistry, pharmaceutical sciences or other relevant discipline) at master level or above, preferably combined with minimum 3-5 years relevant experience. You have a strong background in cell and molecular biology with extensive experience in expansion and differentiation of stem cells, particularly human pluripotent stem cells (hPSCs) in adherent and/or suspension-based culture systems.

The ideal candidate in addition has:

  • Experience in developing and optimising stem cell processes ensuring that desired quality and target cell characteristics are maintained.
  • Experience with Molecular biology techniques, particularly qPCR, ddPCR, NGS, and other gene expression methods
  • Familiarity with generation and interpretation of large datasets
  • Hands on knowledge of cutting-edge techniques in the field of reprogramming.
  • Gene editing experience (CRISPR/Cas9, TALEN, etc) including cell transfection and transduction
  • Experience with DOE models and background in using statistical software (JMP, Minitab, Prism or others)
  • Experience in maintaining organized and detailed up-to-date electronic lab notebook records to support internal documentation needs
  • Attention for details, and drive for problem solving
  • Excellent time management skills and the ability to multitask and contribute to multiple projects under demanding timelines

Additional experience of value:

  • Proven successful development of process and analytical methods, preferably for cell therapy products
  • Familiarity with risk assessments such as FMEA and designing, streamlining, and characterizing processes in the Quality by Design space
  • Working in a CMC setting, including writing procedures and development reports.
  • Support technology transfer of optimized cell manufacturing processes to cGMP-compliant manufacturing facilities within the company or to CMOs
  • Knowledge within regulatory requirements of Good Manufacturing Practices (cGMP)

Since we are working in an international environment; proficiency in English, both written and spoken, is a prerequisite.

As a person, you are open-minded and a good communicator by nature. You have a high level of energy that drives you and inspires your colleagues. You thrive in a changing and dynamic work environment, and in a job that requires you to be flexible, take initiatives and think out of the box when challenges occur. You are a true team-player who enjoys working in close collaboration with colleagues in and out of the laboratory.

Working at Novo Nordisk

At Novo Nordisk, your skills, dedication and ambition help us change lives for the better for patients around the world. In exchange, we offer you an opportunity to work with extraordinary talent and to benefit from a range of possibilities for professional and personal development.

Contact

For further information, please contact Arvind Pradip; phone +45 30 79 67 24 or Pernille Linnert Jensen; phone: +45 30 75 00 78.

Deadline

August 1st 2020

Millions rely on us
To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.


Information og data

Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".

Arbejdsstedet er beliggende i Måløv.

Jobbet er oprettet på vores service den 22.6.2020, men kan have været deaktiveret og genaktiveret igen.

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Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
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