Postdoctoral Position to Study Adipocyte Signalling Using Advanced Functional Genomics

Center for Adipocyte Signaling (ADIPOSIGN), Department of Biochemistry and Molecular Biology invites applications from outstanding postdoctoral candidates who are interested in joining our team effort to understand adipocyte signalling states. The postdoctoral fellow will be affiliated with the Mandrup Group. The position is available from 15 January 2023, or as soon as possible thereafter. Application deadline: 1 December 2022.

ADIPOSIGN and role of postdoc
The ADIPOSIGN centre is funded by a major grant from the Novo Nordisk Foundation (2019-2025). It combines experimental and computational systems approaches to obtain unprecedented insights into how fat cells receive and respond to signals at the level of the (epi)-genome and the cell membrane. Our goal is to understand how the signalling states of adipocytes depend on depot, gender, and genetic variation, and how changes in these signalling states during development of obesity contribute to the pathophysiological consequences of obesity.

As a postdoc in the Mandrup Group and ADIPOSIGN you will use an array of functional genomics approaches to investigate how transcription is regulated by different metabolic states in human and mouse adipocytes. You will have the opportunity to develop your own ideas within our research frame.

The Mandrup Group
The Mandrup Group has a long-standing interest in understanding the molecular cross-talk between transcriptional regulation and metabolism in adipocytes and pancreatic β-cells and to understand the molecular basis for the plasticity of cells in the adipose tissue and endocrine pancreas. We also have a long-time interest in the transcriptional network regulating lineage determination and differentiation of adipocyte progenitors. Our laboratory combines genome-wide studies of factor binding, epigenetic marks and chromatin structure with detailed molecular analyses of the crosstalk between transcriptional regulators. We run an inhouse sequencing platform including single cell sequencing and bioinformatic pipeline.

Susanne Mandrup is Director of ADIPOSIGN as well as the Center of Excellence in Functional Genomics and Tissue Plasticity (ATLAS), and she heads the Functional Genomics and Metabolism Research Unit.
The research unit currently hosts seven independent research groups focusing on various aspects of functional genomics as it pertains to the regulation of cellular differentiation and metabolism. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging, and transgenic mouse work. Strategic research alliances exist with the Odense University Hospital (OUH).

Postdoc qualifications/requirements:
We are looking for a highly motivated, dedicated, and ambitious candidate with:
• A PhD degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Biology
• Experience with research in the field of transcriptional regulation
• Documented experience with cell biology or NGS data analysis
• At least one first-author publication in a relevant journal in the field
• Strong communication and collaborative skills and a desire to work in an interdisciplinary environment
• Proficiency in spoken and written English.

We offer:
• A two-year postdoc position in a stimulating and supportive, international research environment
• Training in a wide range of skills including leadership, research management, communication, networking, presentations, writing of grants and manuscripts etc.
• Mentoring and career development
• Access to state-of-the-art equipment, facilities, and infrastructure
• Opportunity to interact with an extensive network of national and international collaborators
• A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
• Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.

For further information please contact Professor Susanne Mandrup.

Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.

The application must be in English and include the following:
• A letter stating your specific interests, motivation, and qualifications for the project (max. two pages)
• CV incl. education, work/research experience and skills relevant for the position
• Copy of PhD certificate. If awaiting PhD, provide a written statement from the supervisor
• List of publications
• At least two signed reference letters (with referee contact details and relationship). Should your referees wish to send their letters directly to us, please have them directed to the administration mentioning your name and title of the position in the subject line. Please note that the letters need to reach us before application deadline.

Incomplete applications and applications received after the deadline will neither be considered nor evaluated. Shortlisting may be used in the assessment process.

Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Applications must be submitted electronically using the link "Apply online". Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.

Further information for international applicants about entering and working in Denmark.