Industrial PhD Student in Development and Systematization of in-silico Pharmaceutical Process Design

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Are you passionate about solving complex problems at the interface between R&D and large-scale manufacturing? Would you like to pave the way for solving the industrial challenges of the future using modelling & simulation? Then apply for this position as PhD Student in API Manufacturing Development at Novo Nordisk! The position This project is focused on the development of a method and application of in-silico tools using a process systems engineering (PSE) approach for sustainable process synthesis and design of bio-based pharmaceutical manufacturing processes. A bio-based pharmaceutical manufacturing process (raw material to product) for Active Pharmaceutical Ingredients (API) typically consists of 5 main stages; fermentation, recovery and purification (typically referred to as the core API process) and, solvent preparation and utility generation (typically referred to as the auxiliary systems). A major challenge is how to systematically generate and identify sustainable novel process designs related to the core API process and solvent preparation. More specifically, how to navigate, select and verify the best (optimal) unit-operations connected into one seamless process to have uninterrupted delivery of final API product. This research aims to address this challenge by exploring and providing innovation in how to synthesize and design future pharmaceutical process under uncertainty to be fast, flexible, moving at full-speed while being futuristic. The research includes the following tasks:
  • Categorization and consolidation of existing pharmaceutical processes
  • Categorization and consolidation of existing pharmaceutical processes including auxiliary processes.
  • Conceptual method generation and verification for:
    • Synthesis & design to obtain the design space.
    • Robust and risk-aware solutions (with respect to design uncertainty)
    • Innovation including experimental data at lab to full scale.

  • Application of method to design of an industrial pharmaceutical process.
  • Generation of a roadmap for future design of biopharmaceuticals
  • The expected outcome from this research will be a method that can become a standard within industrial manufacturing development for in-silico sustainable pharmaceutical process design in conjunction with experiments and unit-operation design.
    • For information about our enrolment requirements and the general planning of the PhD study program, please see DTU's rules for the PhD education. The recruitment process will be conducted by the supervisor(s) from Novo Nordisk in collaboration with the DTU supervisor(s). The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programs at DTU. The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years. Qualifications You have, or are developing, the following qualifications:
  • An MSc degree, or equivalent, in the following subject areas: chemical/biochemical engineering, process engineering or equivalent
  • Domain knowledge in process systems engineering or modelling & simulation applied to process design, process dynamics or process optimization (for example from Master’s thesis)
  • Experience with equation/object-oriented programming. An asset but not a requirement would be familiarization with one or more of the following: Process simulation (PROII/Aveva Process Simulation, ASPEN Tech, INOSIM), Optimization (GAMS, PYOMO), Programming (Python, Julia or similar)
  • Curious and an appetite for developing AI/ML competences
  • Understanding of how to convey complex information to varying audiences
  • Motivated for solving complex problems applying a systems approach
    • About the department The PhD candidate will be employed by Novo Nordisk and will be enrolled at the industrial PhD program at DTU Chemical and Biochemical Engineering. The PhD project will be supervised by Dr. Mariona Bertran from Novo Nordisk and Prof. Gürkan Sin from PROSYS at DTU Chemical Engineering. The project will mainly be carried out in Product Supply Active Pharmaceutical Ingredients Manufacturing Development at Novo Nordisk in Bagsværd, Denmark, which will provide access to industrially relevant use cases for testing and validation of the project new concepts and methods. Working at Novo Nordisk Together we drive change. At Novo Nordisk, we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing, and sales – we’re all working to move the needle on patient care. Contact For further information please contact Professor Gürkan Sin at [email protected] or Associate Manager Mariona Bertran at +45 3075 8733. Deadline 1st March 2024 - Kindly note that applications will be reviewed on an ongoing basis and interviews conducted continuously. Please submit your application i.e.: CV (incl a few sentences on your motivation) in English, transcripts of Bachelor and Master’s degrees, and a calculation of weighted grade average with course names in English Please be aware that if you are selected for interview, you will be asked to share your CV and personal information with the DTU hiring manager. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.


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    Jobbet er oprettet på vores service den 18.12.2023, men kan have været deaktiveret og genaktiveret igen.

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