PhD fellowship in using the oral cavity as a novel human in-vivo model system to study biofilm
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København N
We are offering a PhD fellowship in Oral Microbiology commencing 1 February 2024, or after agreement.
The overall aim is to demonstrate the feasibility of using the oral cavity as a human model system to study biofilms in-vivo.
The specific aims of the PhD project are:
Accordingly, the PhD student will use advanced computational biology and bioinformatics tools to characterize the oral microbiota in saliva and oral biofilm samples collected in three large clinical trials and compare oral metagenomes with data from non-oral samples.
Project description
The project is a scientific collaboration between three departments at the Faculty of Health and Medical Sciences, University of Copenhagen.
Biofilms are the central act in multiple oral and systemic diseases. A major obstacle for research in biofilms is accessibility of clinical samples. Hence, biofilms are mostly studied in vitro or using animal models. If we are to prevent and treat biofilm-associated diseases more efficiently, there is a need for human in-vivo models, from which data can be translated into clinical conditions.
Gingivitis, periodontitis, and dental caries are the most prevalent biofilm-associated oral diseases. Inflammation is the driving factor of gingivitis and periodontitis, whereas frequent sugar intake fuels the transition towards dental caries. Our group has previously identified significant characteristics of the oral biofilm in periodontitis and dental caries versus oral health. In addition, we have characterized the compositional changes of the biofilm that associates with inadequate oral hygiene, frequent sugar intake, and periodontal treatment. However, we still know nothing about the biology of how oral biofilms adapt to changing environmental conditions, i.e., which bacterial genes that regulates biofilm adaptation during disease-associated perturbations, such as inadequate oral hygiene and frequent sugar intake, and resolution of chronic inflammation after periodontal treatment.
This project will introduce the oral cavity as a novel in-vivo model system with numerous applications. As a proof of principle, the project should demonstrate the feasibility of using bacterial genes as biomarkers of gingivitis, periodontitis, and dental caries, which will lay the foundation for molecular-based risk assessment. In addition, the project will validate candidate biomarker genes in public available datasets to determine their role in non-oral inflammatory conditions, such as type 2 diabetes and cardiovascular diseases. Hence, the project will document the practicability of using the oral cavity as an in-vivo model system, as alternative to in-vitro setups and animal models for studies on biofilm-associated diseases of both oral and non-oral origin.
Supervision
The project will be carried out under the supervision of:
Job description
Your key tasks as a PhD student at the Faculty of Health and Medical Sciences are:
Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, i.e., molecular biology, bioinformatics, data science or odontology. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).
Terms of employment
The employment as a PhD fellow is full time (37 working hours per week in average) and for 3 years. The start date is 1 February 2024, or after agreement.
It is conditioned upon the applicant’s successful enrollment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen, as well as a positive assessment of the 1-year research assistant position. Enrollment at the Graduate School requires submission and acceptance of an application for the specific project formulated by the applicant (for more information, please see https://healthsciences.ku.dk/phd/guidelines/).
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the faculty’s rules on achieving the degree. Salary, pension, and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 28,993 /approx. EUR 3,865 (October 2023-level) plus pension.
Questions
For further information regarding the position, please contact Professor Daniel Midjord-Belstrøm ([email protected]).
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:
Application deadline: Sunday 5 November 2023, 23.59 pm CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills, and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant will have the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You find information about the recruitment process at: http://employment.ku.dk/faculty/recruitment-process/.
The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The Faculty of Health and Medical Sciences comprises approximately 7,815 students, 2,113 researchers and 3,793 employees. The faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.
Kilde: Jobnet.dk
The overall aim is to demonstrate the feasibility of using the oral cavity as a human model system to study biofilms in-vivo.
The specific aims of the PhD project are:
- To identify bacterial genes which are affected during initiation and resolution of oral inflammation as well as sugar stress.
- To test if specific genes are biomarkers of different disease trajectories of gingivitis, periodontitis, and dental caries.
- To validate generalizability of identified genes in datasets of non-oral origin.
Accordingly, the PhD student will use advanced computational biology and bioinformatics tools to characterize the oral microbiota in saliva and oral biofilm samples collected in three large clinical trials and compare oral metagenomes with data from non-oral samples.
Project description
The project is a scientific collaboration between three departments at the Faculty of Health and Medical Sciences, University of Copenhagen.
Biofilms are the central act in multiple oral and systemic diseases. A major obstacle for research in biofilms is accessibility of clinical samples. Hence, biofilms are mostly studied in vitro or using animal models. If we are to prevent and treat biofilm-associated diseases more efficiently, there is a need for human in-vivo models, from which data can be translated into clinical conditions.
Gingivitis, periodontitis, and dental caries are the most prevalent biofilm-associated oral diseases. Inflammation is the driving factor of gingivitis and periodontitis, whereas frequent sugar intake fuels the transition towards dental caries. Our group has previously identified significant characteristics of the oral biofilm in periodontitis and dental caries versus oral health. In addition, we have characterized the compositional changes of the biofilm that associates with inadequate oral hygiene, frequent sugar intake, and periodontal treatment. However, we still know nothing about the biology of how oral biofilms adapt to changing environmental conditions, i.e., which bacterial genes that regulates biofilm adaptation during disease-associated perturbations, such as inadequate oral hygiene and frequent sugar intake, and resolution of chronic inflammation after periodontal treatment.
This project will introduce the oral cavity as a novel in-vivo model system with numerous applications. As a proof of principle, the project should demonstrate the feasibility of using bacterial genes as biomarkers of gingivitis, periodontitis, and dental caries, which will lay the foundation for molecular-based risk assessment. In addition, the project will validate candidate biomarker genes in public available datasets to determine their role in non-oral inflammatory conditions, such as type 2 diabetes and cardiovascular diseases. Hence, the project will document the practicability of using the oral cavity as an in-vivo model system, as alternative to in-vitro setups and animal models for studies on biofilm-associated diseases of both oral and non-oral origin.
Supervision
The project will be carried out under the supervision of:
- Primary supervisor: Professor, Dr Odont, PhD, DDS Daniel Midjord-Belstrøm, Section for Clinical Oral Microbiology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen.
- Co-supervisor: Professor, Dr Tech, Michael Givskov, Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen.
- Co-supervisor: Associate Professor, PhD, Martin Sikora, Globe Institute, Lundbeck Foundation for GeoGenetics Centre, Faculty of Health and Medical Sciences, University of Copenhagen.
- Co-supervisor: Associate Professor, PhD, Hannes Schroeder, Globe Institute, Lundbeck Foundation for GeoGenetics Centre, Faculty of Health and Medical Sciences, University of Copenhagen.
Job description
Your key tasks as a PhD student at the Faculty of Health and Medical Sciences are:
- Carrying through an independent research project under supervision.
- Completing PhD courses or other equivalent education corresponding to approximately 30 ECTS points.
- Participating in active research environments including a stay at another research team.
- Obtaining experience with teaching or other types of dissemination related to your PhD project.
- Teaching and disseminating your knowledge.
- Writing a PhD thesis on the grounds of your project.
Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, i.e., molecular biology, bioinformatics, data science or odontology. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).
Terms of employment
The employment as a PhD fellow is full time (37 working hours per week in average) and for 3 years. The start date is 1 February 2024, or after agreement.
It is conditioned upon the applicant’s successful enrollment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen, as well as a positive assessment of the 1-year research assistant position. Enrollment at the Graduate School requires submission and acceptance of an application for the specific project formulated by the applicant (for more information, please see https://healthsciences.ku.dk/phd/guidelines/).
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the faculty’s rules on achieving the degree. Salary, pension, and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 28,993 /approx. EUR 3,865 (October 2023-level) plus pension.
Questions
For further information regarding the position, please contact Professor Daniel Midjord-Belstrøm ([email protected]).
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:
- Motivated letter of application (max. one page).
- CV incl. education, experience, language skills and other skills relevant for the position.
- Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
- Publication list (if possible).
Application deadline: Sunday 5 November 2023, 23.59 pm CET.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills, and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant will have the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You find information about the recruitment process at: http://employment.ku.dk/faculty/recruitment-process/.
The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The Faculty of Health and Medical Sciences comprises approximately 7,815 students, 2,113 researchers and 3,793 employees. The faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i København N.
Jobbet er oprettet på vores service den 10.10.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- København N
- Søndag den 05. november 2023
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