PhD in the Circadian Control of Mitochondrial Metabolism and Mitophagy
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København N
Faculty of Health and Medical Sciences
University of Copenhagen
The University of Copenhagen is seeking a highly motivated and talented PhD fellow to commence 1 March 2024, at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen.
About Us
Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in cardiometabolic health and disease, and to accelerate this knowledge towards new prevention and treatment strategies.
The Center has around 260 employees, spread across 21 research groups and 5 technology platforms, who work in a vibrant international research environment with a strong focus on interdisciplinary collaboration.
The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life. You can read more about CBMR at www.cbmr.ku.dk.
Our Research
The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise and nutrient provision to identify novel translational strategies for prevention and treatment of metabolic disease. You can read more about the Zierath Group here.
Project Description
You will be part of a project investigating how mitochondrial metabolism is controlled across the circadian cycle. Our preliminary evidence implicates mitophagy, the turnover of mitochondria, in the control of liver metabolism in mice. This project will build upon that foundational knowledge to investigate the environmental cues and molecular transducers that regulate circadian mitochondrial metabolism. In addition, we will investigate how this process may be dysregulated in disease states such as obesity and type 2 diabetes, using animal models and human clinical samples.
You will join a multi-disciplinary research team working on basic and applied research questions related to circadian rhythms, metabolism and exercise. Your tasks will be to support the research endeavours within the group by performing wet-lab-based experiments to accelerate the delivery of our programme of research. For example, these tasks could encompass microscopy, qPCR experiments, immunoblotting, and genotyping of our transgenic animal lines.
Principal supervisor isProfessor Juleen Zierath, [email protected].
Start: 1 March 2024
Duration: 3 years as PhD fellow.
Profile
The PhD fellowship is aimed at early-career researchers with a basic science background.
Required skills and qualifications:
Desired skills:
Eligibility
The PhD fellowships are open for applicants that hold a Master’s degree equivalent to a Danish master’s degree (two years). The Master’s degree has to be obtained before 1 March 2024.
Terms of Employment
The employment consists of 3 years as PhD fellow. Starting date is 1 March 2024.
The employment as PhD fellow is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant. The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State.
Questions
For further information about the position, please contact Professor Juleen Zierath at [email protected]. For questions regarding the recruitment procedure, please contact HR at [email protected].
General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website. The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark.
Application Procedure
Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:
Application Deadline: 22 October 2023, 23.59pm CET
We reserve the right not to consider material received after the deadline and not to consider applications that do not live up to the abovementioned requirements.
The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.
The applicant will be assessed according to Ministerial Order No. 242 of March 13, 2012, on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal backgrounds.
Kilde: Jobnet.dk
University of Copenhagen
The University of Copenhagen is seeking a highly motivated and talented PhD fellow to commence 1 March 2024, at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen.
About Us
Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in cardiometabolic health and disease, and to accelerate this knowledge towards new prevention and treatment strategies.
The Center has around 260 employees, spread across 21 research groups and 5 technology platforms, who work in a vibrant international research environment with a strong focus on interdisciplinary collaboration.
The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life. You can read more about CBMR at www.cbmr.ku.dk.
Our Research
The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise and nutrient provision to identify novel translational strategies for prevention and treatment of metabolic disease. You can read more about the Zierath Group here.
Project Description
You will be part of a project investigating how mitochondrial metabolism is controlled across the circadian cycle. Our preliminary evidence implicates mitophagy, the turnover of mitochondria, in the control of liver metabolism in mice. This project will build upon that foundational knowledge to investigate the environmental cues and molecular transducers that regulate circadian mitochondrial metabolism. In addition, we will investigate how this process may be dysregulated in disease states such as obesity and type 2 diabetes, using animal models and human clinical samples.
You will join a multi-disciplinary research team working on basic and applied research questions related to circadian rhythms, metabolism and exercise. Your tasks will be to support the research endeavours within the group by performing wet-lab-based experiments to accelerate the delivery of our programme of research. For example, these tasks could encompass microscopy, qPCR experiments, immunoblotting, and genotyping of our transgenic animal lines.
Principal supervisor isProfessor Juleen Zierath, [email protected].
Start: 1 March 2024
Duration: 3 years as PhD fellow.
Profile
The PhD fellowship is aimed at early-career researchers with a basic science background.
Required skills and qualifications:
- Master’s degree in Biology, Biochemistry, Molecular Biology, Molecular Biomedicine, or related sciences Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).
- Experience and knowledge in microscopy, particularly confocal microscopy
- Certified with FELASA laboratory animal science
- You have an active interest in metabolic research
- You have proven an ability to envision, plan and execute a research project
- Excellent team-working skills
- Good English skills, written and spoken
Desired skills:
- Experience studying mitochondrial biology
- Experience in proteomics, particularly in sample preparation
- Additional wet-lab skills (e.g. qPCR, immunoblotting etc) are desirable
- Previous experience managing breeding and experimental projects in rodents
- Experience studying the mito-qc mouse model is desirable
Eligibility
The PhD fellowships are open for applicants that hold a Master’s degree equivalent to a Danish master’s degree (two years). The Master’s degree has to be obtained before 1 March 2024.
Terms of Employment
The employment consists of 3 years as PhD fellow. Starting date is 1 March 2024.
The employment as PhD fellow is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant. The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Taxation and The Danish Confederation of Professional Associations on Academics in the State.
Questions
For further information about the position, please contact Professor Juleen Zierath at [email protected]. For questions regarding the recruitment procedure, please contact HR at [email protected].
General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website. The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark.
Application Procedure
Your online application must be submitted in English via the ‘Apply now’ link below. Furthermore, your application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page)
- CV incl. education, experience, language skills and other skills relevant to the position
- Certified copy of original Master’s diploma and transcript of records in the original language, including an authorized English translation if issued in another language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
- List of publications
- References (name and contact details of at least two references)
Application Deadline: 22 October 2023, 23.59pm CET
We reserve the right not to consider material received after the deadline and not to consider applications that do not live up to the abovementioned requirements.
The Further Process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.
The applicant will be assessed according to Ministerial Order No. 242 of March 13, 2012, on the Appointment of Academic Staff at Universities.
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal backgrounds.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i København N.
Jobbet er oprettet på vores service den 10.10.2023, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- København N
- Søndag den 22. oktober 2023
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