PhD project at Statens Serum Institut
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The Department of Infectious Disease Immunology, Center for Vaccine Research is looking for a dedicated and goal orientated PhD-student.
The department
The Department of Infectious Disease Immunology focuses on research and development of next-generation vaccines, primarily within mucosal infections such as chlamydia, tuberculosis, ETEC, and vaccine adjuvants for induction of tailored immune responses. The department conducts both basic and translational research and is highly rated internationally. As part of Statens Serum Institut (SSI) Center for Vaccine Research, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the European Commission and the Danish Research Council.
The project
Background
Oral delivery of subunit vaccines is a desirable method for vaccination of both humans and animals, however there are several obstacles hindering activation of an immune response to mucosally delivered vaccines. The main obstacle to overcome is the natural oral tolerance to harmless foreign materials/antigens in the intestinal lumen. In the gastro-associated lymphoid tissue (GALT) the main immunological induction sites are Peyer’s patches (PPs), where microfold (M) cells, embedded in the epithelium directly above the PPs, sample particles from the lumen and transport them across the epithelium to the immune cells underneath the epithelium. Antigens are also sampled across epithelial cells and delivered to dendritic cells in the lamina propria. Targeting enhanced cellular uptake of antigens by M cells or epithelial cells is therefore a promising strategy for delivery of vaccines to the GALT. In this project, we will investigate the importance of protein design for immunogenicity of subunit vaccine antigens delivered by the oral route.
Hypothesis
Protein design can enhance the cellular uptake of the protein and increase immunogenicity for efficient induction of systemic and local immune responses after oral delivery.
The project
The PhD project is part of the Vax2Muc project funded by Horizon Europe https://www.vax2muc.eu/ where we evaluate an oral vaccine against Helicobacter pylori in a phase I clinical trial, and perform research to advance GMP manufacturing, novel vaccine technologies and strategies for optimised mucosal immunity in the gastrointestinal tract.
In the PhD project, in vitro studies with cell lines and in vivo studies in mice, rats and potentially pigs will be employed for assessment of trans-epithelial uptake and protein immunogenicity. Uptake of vaccine particles by M cells or other relevant cells may be analysed by flow cytometry or confocal microscopy. Immunogenicity studies evaluating local and systemic immune responses induced by orally administered vaccines will be used to evaluate the induction of antigen-specific humoral (IgA), CD4 and CD8 T-cell responses.
Your education, experience and qualifications
We are looking for a dedicated student with an interest in mucosal immunology and vaccine research. The preferred candidate is a highly motivated student holding a Master´s degree in Life Sciences and have the following qualifications:
Terms of employment
The employment is of 3 years duration.
Employment will be in accordance with the collective agreement between the Ministry of Taxation and Akademikerne/AC and the Danish Ministry of Taxation.
Timeline and contact information
The last day for application is January 31st, 2024 and interviews are scheduled for weeks 6 and 7.
The starting date is April 1, 2024, or by agreement.
For further details and informal enquiries please contact head of veterinary vaccine research Gregers Jungersen at +45 3268 8592 or scientist Gitte Erbs at +45 3268 3786.
Kilde: Jobnet.dk
The department
The Department of Infectious Disease Immunology focuses on research and development of next-generation vaccines, primarily within mucosal infections such as chlamydia, tuberculosis, ETEC, and vaccine adjuvants for induction of tailored immune responses. The department conducts both basic and translational research and is highly rated internationally. As part of Statens Serum Institut (SSI) Center for Vaccine Research, we can efficiently move products from research into clinical trials. We collaborate closely with a large number of institutions and are externally funded by e.g. the European Commission and the Danish Research Council.
The project
Background
Oral delivery of subunit vaccines is a desirable method for vaccination of both humans and animals, however there are several obstacles hindering activation of an immune response to mucosally delivered vaccines. The main obstacle to overcome is the natural oral tolerance to harmless foreign materials/antigens in the intestinal lumen. In the gastro-associated lymphoid tissue (GALT) the main immunological induction sites are Peyer’s patches (PPs), where microfold (M) cells, embedded in the epithelium directly above the PPs, sample particles from the lumen and transport them across the epithelium to the immune cells underneath the epithelium. Antigens are also sampled across epithelial cells and delivered to dendritic cells in the lamina propria. Targeting enhanced cellular uptake of antigens by M cells or epithelial cells is therefore a promising strategy for delivery of vaccines to the GALT. In this project, we will investigate the importance of protein design for immunogenicity of subunit vaccine antigens delivered by the oral route.
Hypothesis
Protein design can enhance the cellular uptake of the protein and increase immunogenicity for efficient induction of systemic and local immune responses after oral delivery.
The project
The PhD project is part of the Vax2Muc project funded by Horizon Europe https://www.vax2muc.eu/ where we evaluate an oral vaccine against Helicobacter pylori in a phase I clinical trial, and perform research to advance GMP manufacturing, novel vaccine technologies and strategies for optimised mucosal immunity in the gastrointestinal tract.
In the PhD project, in vitro studies with cell lines and in vivo studies in mice, rats and potentially pigs will be employed for assessment of trans-epithelial uptake and protein immunogenicity. Uptake of vaccine particles by M cells or other relevant cells may be analysed by flow cytometry or confocal microscopy. Immunogenicity studies evaluating local and systemic immune responses induced by orally administered vaccines will be used to evaluate the induction of antigen-specific humoral (IgA), CD4 and CD8 T-cell responses.
Your education, experience and qualifications
We are looking for a dedicated student with an interest in mucosal immunology and vaccine research. The preferred candidate is a highly motivated student holding a Master´s degree in Life Sciences and have the following qualifications:
- Training in immunology
- Research experience with in vitro cell line work and immunological assays e.g. Flow Cytometry and ELISA
- Hard-working and self-motivated mentality
- Dynamic, independent and goal orientated
- Critical and creative thinking
Terms of employment
The employment is of 3 years duration.
Employment will be in accordance with the collective agreement between the Ministry of Taxation and Akademikerne/AC and the Danish Ministry of Taxation.
Timeline and contact information
The last day for application is January 31st, 2024 and interviews are scheduled for weeks 6 and 7.
The starting date is April 1, 2024, or by agreement.
For further details and informal enquiries please contact head of veterinary vaccine research Gregers Jungersen at +45 3268 8592 or scientist Gitte Erbs at +45 3268 3786.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Øvrige", og befinder sig i kategorien "Øvrige stillinger".
Arbejdsstedet er beliggende i København S.
Jobbet er oprettet på vores service den 10.1.2024, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Øvrige
- København S
- Onsdag den 31. januar 2024
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| Dato | Alle jobs som øvrige |
|---|---|
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