PhD position in cardiac proteomics with focus on ARVC
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Description
We are seeking a PhD fellow to apply proteomics strategies to investigate molecular changes in Arrhythmogenic Right Ventricular Cardiomyopathy. The PhD fellow shall focus on experimental and analytical strategies within quantitative proteomics and phosphoproteomics to outline molecular cardiac changes associated with the disease. The fellow will work with human and animal tissue samples as well as perform cell based work. The position provides an opportunity to develop expertise in quantitative mass spectrometry, cutting-edge discovery proteomics and integrative analysis of human, animal and cell based studies.
The candidate will be part of the Cardiac Proteomics group led by Professor Alicia Lundby at the Department of Biomedical Sciences at the University of Copenhagen, Denmark. The research focus of the Cardiac Proteomics group is to use high-resolution LC-MS/MS to obtain insights beyond the current molecular understanding of the heart; both at the level of protein expression, as well as phosphorylation mediated protein signaling. We work closely together with cardiologists to ensure high impact and translatability of our research.
Responsibilities and Tasks
The successful candidate will:
Qualifications
The preferred applicant will possess an excellent academic track record and solid research experience and be highly motivated to perform science to extract novel findings of importance to cardiac (patho)physiology.
We offer
You will become part of a research environment spanning cardiologists, geneticists performing next generation sequencing on cardiac patient samples, experimental groups performing follow-up experiments in model organisms such as zebrafish, mouse and pig as well as molecular biologists. We strive for academic excellence, collegial respect and freedom tempered by responsibility.
Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations (AC). The allowance will be agreed with the relevant union.
Workplace and period of employment
The Panum Institute, University of Copenhagen, Denmark.
The period of employment is 3 years.
Further information
Further information may be obtained from Professor Alicia Lundby: [email protected].
You can read more about the Cardiac Proteomics Group at www.lundbylab.com
You can read more about the Department of Biomedical Sciences at www.bmi.ku.dk/english
Application procedure
Please submit your online application no later than May 26 2021. Apply by clinking "Apply now" below, or via https://employment.ku.dk/phd/.
The File Must Include
Applications must be submitted as containing all materials to be given consideration. Attach all your materials in English in one PDF file. The application should contain:
Applications and enclosures received after the deadline will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
Kilde: Jobnet.dk
We are seeking a PhD fellow to apply proteomics strategies to investigate molecular changes in Arrhythmogenic Right Ventricular Cardiomyopathy. The PhD fellow shall focus on experimental and analytical strategies within quantitative proteomics and phosphoproteomics to outline molecular cardiac changes associated with the disease. The fellow will work with human and animal tissue samples as well as perform cell based work. The position provides an opportunity to develop expertise in quantitative mass spectrometry, cutting-edge discovery proteomics and integrative analysis of human, animal and cell based studies.
The candidate will be part of the Cardiac Proteomics group led by Professor Alicia Lundby at the Department of Biomedical Sciences at the University of Copenhagen, Denmark. The research focus of the Cardiac Proteomics group is to use high-resolution LC-MS/MS to obtain insights beyond the current molecular understanding of the heart; both at the level of protein expression, as well as phosphorylation mediated protein signaling. We work closely together with cardiologists to ensure high impact and translatability of our research.
Responsibilities and Tasks
The successful candidate will:
- Perform unbiased data-driven investigations of cardiac tissue samples to quantify protein and signaling changes in hearts in connection to ARVC.
- Perform proximity ligation proteomics experiments in an animal model of ARVC.
- Perform method studies to evaluate feasibility of quantitative investigations from clinical heart samples.
- Make biological interpretation of data and communicate the results internally and externally.
- The successful candidate will be working in a team of scientists across multiple scientific fields focused on improving our molecular understanding of cardiac pathophysiology and to solve fundamental challenges in cardiac research.
Qualifications
- Master degree in Biochemistry or equivalent
- Hands-on experience in high-resolution mass spectrometry (LC-MS/MS)
- Experience with Cardiac Proteomics
- Hands-on experience with proximity ligation proteomics
- Practical skills in protein chemistry and cell culture
- Experience with quantitative proteomics experiments
- Ability and enthusiasm to learn new methods/techniques
- Good communication skills in English, both oral and written
- Highly ambitious and self-driven
- Previously demonstrated a capacity for excellence
- Experience with proteomics data analysis (such as MaxQuant, Perseus, R)
- Proven experience in high throughput large-scale datasets
- Strong work ethics and team player mentality
The preferred applicant will possess an excellent academic track record and solid research experience and be highly motivated to perform science to extract novel findings of importance to cardiac (patho)physiology.
We offer
- An interesting and challenging job in an international environment focusing on cardiac research with state of the art facilities.
- A challenging and stimulating work environment, at the edge of IT technologies and the latest research innovations
- Start date: September 1 2021
You will become part of a research environment spanning cardiologists, geneticists performing next generation sequencing on cardiac patient samples, experimental groups performing follow-up experiments in model organisms such as zebrafish, mouse and pig as well as molecular biologists. We strive for academic excellence, collegial respect and freedom tempered by responsibility.
Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations (AC). The allowance will be agreed with the relevant union.
Workplace and period of employment
The Panum Institute, University of Copenhagen, Denmark.
The period of employment is 3 years.
Further information
Further information may be obtained from Professor Alicia Lundby: [email protected].
You can read more about the Cardiac Proteomics Group at www.lundbylab.com
You can read more about the Department of Biomedical Sciences at www.bmi.ku.dk/english
Application procedure
Please submit your online application no later than May 26 2021. Apply by clinking "Apply now" below, or via https://employment.ku.dk/phd/.
The File Must Include
Applications must be submitted as containing all materials to be given consideration. Attach all your materials in English in one PDF file. The application should contain:
- application (cover letter)
- CV
- diploma (an official translation into English)
- list of publications
- Contact details for two referees
Applications and enclosures received after the deadline will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i København N.
Jobbet er oprettet på vores service den 12.5.2021, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- København N
- Tirsdag den 25. maj 2021
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