PhD Fellow – Application of continuous in vivo mutagenesis-based directed evolution met...
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Frederiksberg C
Department of Plant and Environmental Sciences is seeking a highly motivated, creative and independent PhD student to work on the development of innovative approaches for the production of valuable proteins in engineered yeast through synthetic biology. The successful candidate will join a vibrant international research environment and will be integrated at the “Biochemical Engineering” research group headed by Associate Professor Sotirios Kampranis ([email protected]) at the Section of Plant Biochemistry, Department of Plant and Environmental Sciences. The position is for 36 months. Starting date will be June 1st 2020, or as soon as possible thereafter.
Directed evolution consists of a continuous cycle of diversification of a protein by natural or induced mutagenesis and selection of proteins with desired properties. It has been applied in creating novel enzymes but can be used for the engineering of any kind of proteins. Our main focus is to develop directed evolution methods in yeast, coupled with dynamic selection for engineering of high-value proteins. The incoming scientist will focus on setting up and applying a novel CRISPR CAS9 based universal yeast continuous mutation system and selection systems including our in-house biosensor platform and advanced protein-protein interaction screening methods for development of novel enzymes and other valuable proteins.
Skills and experience required or highly desired for the position:
The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:
Formal requirements
Applicants should hold an MSc degree in in a related research area (e.g. molecular biology, metabolic engineering, enzymology, biochemistry with good results and good English skills. As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience.
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
The starting salary is currently at a minimum DKK 328.355 (approx. €43,750) including annual supplement (+ pension at a minimum DKK 53,360). Negotiation for salary supplement is possible.
Application Procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Please include
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
The deadline for applications is 19 March 2020 23:59 GMT +1. Applications received after the deadline for applications will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process athttp://employment.ku.dk/faculty/recruitment-process/.
Questions
For more information contact Associate Professor Sotirios Kampranis ([email protected]) or Assistant Professor Irini Pateraki ([email protected])
General information about PhD programmes at SCIENCE is available at https://www.science.ku.dk/phd.
Kilde: Jobnet.dk
Directed evolution consists of a continuous cycle of diversification of a protein by natural or induced mutagenesis and selection of proteins with desired properties. It has been applied in creating novel enzymes but can be used for the engineering of any kind of proteins. Our main focus is to develop directed evolution methods in yeast, coupled with dynamic selection for engineering of high-value proteins. The incoming scientist will focus on setting up and applying a novel CRISPR CAS9 based universal yeast continuous mutation system and selection systems including our in-house biosensor platform and advanced protein-protein interaction screening methods for development of novel enzymes and other valuable proteins.
Skills and experience required or highly desired for the position:
- Broad curiosity in biological questions and open-mindedness to cross-disciplinary research.
- Knowledge of specialized metabolism with special focus on terpenoids
- Theoretical and hands-on expertise in molecular biology and biochemistry
- Enthusiasm and good interpersonal and communication skills with the ability to work and collaborate with others, including the supervision and mentoring of postgraduate students.
- Ability to work independently and see projects through to completion.
- Strong scientific writing skills and publication record.
The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:
- to independently design and execute experiments and manage data analysis
- to record experimental results in a professional manner
- to attend and pass PhD courses
- to draft and submit at research articles as the primary author to peer-review journal
- to write and submit a high-quality PhD thesis
- to teach BSc and MSc students in courses and supervise in research laboratories
- to disseminate the research results at conferences etc.
- to stay at an external research institution for a few months, preferably abroad
- to execute GLP and ensure safety
- to contribute to the maintenance of shared instruments
- to participate in Departmental and Section activities
Formal requirements
Applicants should hold an MSc degree in in a related research area (e.g. molecular biology, metabolic engineering, enzymology, biochemistry with good results and good English skills. As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience.
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
The starting salary is currently at a minimum DKK 328.355 (approx. €43,750) including annual supplement (+ pension at a minimum DKK 53,360). Negotiation for salary supplement is possible.
Application Procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Please include
- Cover Letter. Please state your motivation and describe how your background contributes to the project. Please also include full contact details (name, address, telephone & email) of 1-3 professional referees (Maximum 2 pages including list of referees)
- CV and list of publications
- Diploma and transcripts for BSc and MSc degrees
- Other information for consideration
The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.
The deadline for applications is 19 March 2020 23:59 GMT +1. Applications received after the deadline for applications will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process athttp://employment.ku.dk/faculty/recruitment-process/.
Questions
For more information contact Associate Professor Sotirios Kampranis ([email protected]) or Assistant Professor Irini Pateraki ([email protected])
General information about PhD programmes at SCIENCE is available at https://www.science.ku.dk/phd.
Kilde: Jobnet.dk
Information og data
Denne ledige stilling har jobtypen "Forsker", og befinder sig i kategorien "Sundhed og forskning".
Arbejdsstedet er beliggende i Frederiksberg C.
Jobbet er oprettet på vores service den 5.3.2020, men kan have været deaktiveret og genaktiveret igen.
Dagligt opdateret: Dette job opdateres dagligt ud fra jobudbyderens hjemmeside via vores søgemaskineteknologi og er aktivt lige nu.
- Forsker
- Frederiksberg C
- Torsdag den 19. marts 2020
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